ArticleHeart (British Cardiac Society)2016
Improvements in ECG accuracy for diagnosis of left ventricular hypertrophy in obesity.
Article in Heart (British Cardiac Society), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A meta-analytic evaluation of the diagnostic accuracy of the electrocardiographic Peguero-Lo Presti criterion for left ventricular hypertrophy.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Potential of R Wave in aVL Lead in Cardiovascular Risk Assessment.Biomedicines · 2026Article
- Correlations Between Novel Adiposity Indices and Electrocardiographic Evidence of Left Ventricular Hypertrophy in Individuals with Arterial Hypertension.Journal of personalized medicine · 2025Article
- Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes.Cardiovascular diabetology · 2024Article
- Left ventricular hypertrophy: an ECG-based study of prevalence and risk factors in a multiethnic population.Open heart · 2023Article
- Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry.Frontiers in endocrinology · 2023Article
- CoAt-Mixer: Self-attention deep learning framework for left ventricular hypertrophy using electrocardiography.PloS one · 2023Article
- Clinical applicability and diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy diagnosis in older adults.Scientific reports · 2021Article
- Electrocardiographic Versus Echocardiographic Left Ventricular Hypertrophy in Severe Aortic Stenosis.Journal of clinical medicine · 2021Article
- Article
- T-wave and its association with myocardial fibrosis on cardiovascular magnetic resonance examination.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Prognostic significance of body mass index-adjusted criteria for left ventricular hypertrophy.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- The use of cardiovascular magnetic resonance for the assessment of left ventricular hypertrophy.Cardiovascular diagnosis and therapy · 2020Review
- Optimized electrocardiographic criteria for the detection of left ventricular hypertrophy in obesity patients.Clinical cardiology · 2020Article
- Circulating biomarkers in the early detection of hypertensive heart disease: usefulness in the developing world.Cardiovascular diagnosis and therapy · 2020Review
- Electrocardiographic criteria for left ventricular hypertrophy in aortic valve stenosis: Correlation with echocardiographic parameters.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans.PloS one · 2019Article
- Comparison of Left Ventricular Hypertrophy by Electrocardiography and Echocardiography in Children Using Analytics Tool.Pediatric cardiology · 2018Article
- Causal Pathways from Blood Pressure to Larger Qrs Amplitudes a Mendelian Randomization Study.Scientific reports · 2018Article
- A Fortified Method to Screen and Detect Left Ventricular Hypertrophy in Asymptomatic Hypertensive Adults: A Korean Retrospective, Cross-Sectional Study.International journal of hypertension · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesThe electrocardiogram (ECG) is the most commonly used tool to screen for left ventricular hypertrophy (LVH), and yet current diagnostic criteria are insensitive in modern increasingly overweight society. We propose a simple adjustment to improve diagnostic accuracy in different body weights and improve the sensitivity of this universally available technique.
methodsOverall, 1295 participants were included-821 with a wide range of body mass index (BMI 17.1-53.3 kg/m(2)) initially underwent cardiac magnetic resonance evaluation of anatomical left ventricular (LV) axis, LV mass and 12-lead surface ECG in order to generate an adjustment factor applied to the Sokolow-Lyon criteria. This factor was then validated in a second cohort (n=520, BMI 15.9-63.2 kg/m(2)).
resultsWhen matched for LV mass, the combination of leftward anatomical axis deviation and increased BMI resulted in a reduction of the Sokolow-Lyon index, by 4 mm in overweight and 8 mm in obesity. After adjusting for this in the initial cohort, the sensitivity of the Sokolow-Lyon index increased (overweight: 12.8% to 30.8%, obese: 3.1% to 27.2%) approaching that seen in normal weight (37.8%). Similar results were achieved in the validation cohort (specificity increased in overweight: 8.3% to 39.1%, obese: 9.4% to 25.0%) again approaching normal weight (39.0%). Importantly, specificity remained excellent (>93.1%).
conclusionsAdjusting the Sokolow-Lyon index for BMI (overweight +4 mm, obesity +8 mm) improves the diagnostic accuracy for detecting LVH. As the ECG, worldwide, remains the most widely used screening tool for LVH, implementing these findings should translate into significant clinical benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.