ArticleJournal of neurophysiology2016
Spike synchrony generated by modulatory common input through NMDA-type synapses.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease.Molecular biomedicine · 2026Article
- Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.PLoS computational biology · 2025Article
- Event-driven figure-ground organisation model for the humanoid robot iCub.Nature communications · 2025Article
- Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.Frontiers in systems neuroscience · 2025Article
- A microcircuit model involving parvalbumin, somatostatin, and vasoactive intestinal polypeptide inhibitory interneurons for the modulation of neuronal oscillation during visual processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Disinhibitory circuit mediated by connections from vasoactive intestinal polypeptide to somatostatin interneurons underlies the paradoxical decrease in spike synchrony with increased border ownership selective neuron firing rate.Frontiers in computational neuroscience · 2022Article
- A Neuromorphic Proto-Object Based Dynamic Visual Saliency Model With a Hybrid FPGA Implementation.IEEE transactions on biomedical circuits and systems · 2021Article
- Analysis of spiking synchrony in visual cortex reveals distinct types of top-down modulation signals for spatial and object-based attention.PLoS computational biology · 2021Article
- Searching for object pointers in the visual cortex.Journal of neurophysiology · 2020Article
- Interactions Elicited by the Contradiction Between Figure Direction Discrimination and Figure-Ground Segregation.Frontiers in psychology · 2018Article
- Figure-ground organization in the visual cortex: does meaning matter?Journal of neurophysiology · 2018Article
- A recurrent neural model for proto-object based contour integration and figure-ground segregation.Journal of computational neuroscience · 2017Article
- Modeling the Time-Course of Responses for the Border Ownership Selectivity Based on the Integration of Feedforward Signals and Visual Cortical Interactions.Frontiers in psychology · 2016Article
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Abstract
Common excitatory input to neurons increases their firing rates and the strength of the spike correlation (synchrony) between them. Little is known, however, about the synchronizing effects of modulatory common input. Here, we show that modulatory common input with the slow synaptic kinetics of N-methyl-d-aspartate (NMDA) receptors enhances firing rates and also produces synchrony. Tight synchrony (correlations on the order of milliseconds) always increases with modulatory strength. Unexpectedly, the relationship between strength of modulation and strength of loose synchrony (tens of milliseconds) is not monotonic: The strongest loose synchrony is obtained for intermediate modulatory amplitudes. This finding explains recent neurophysiological results showing that in cortical areas V1 and V2, presumed modulatory top-down input due to contour grouping increases (loose and tight) synchrony but that additional modulatory input due to top-down attention does not change tight synchrony and actually decreases loose synchrony. These neurophysiological findings are understood from our model of integrate-and-fire neurons under the assumption that contour grouping as well as attention lead to additive modulatory common input through NMDA-type synapses. In contrast, circuits with common projections through model α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors did not exhibit the paradoxical decrease of synchrony with increased input. Our results suggest that NMDA receptors play a critical role in top-down response modulation in the visual cortex.
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