ArticleJournal of neurophysiology2016
Subretinal electrical stimulation reveals intact network activity in the blind mouse retina.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types.The Journal of physiology · 2025Article
- Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors.Nature biomedical engineering · 2024Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- Assessment of chemotherapeutic effects on cancer cells using adhesion noise spectroscopy.Frontiers in bioengineering and biotechnology · 2024Article
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- High spatial resolution artificial vision inferred from the spiking output of retinal ganglion cells stimulated by optogenetic and electrical means.Frontiers in cellular neuroscience · 2022Article
- A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine.Microsystems & nanoengineering · 2022Article
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model.Scientific reports · 2021Article
- Neuromodulation using electroosmosis.Journal of neural engineering · 2021Article
- Efficient photocapacitors via ternary hybrid photovoltaic optimization for photostimulation of neurons.Biomedical optics express · 2020Article
- Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina.Scientific reports · 2020Article
- Low-Temperature Atomic Layer Deposited Oxide on Titanium Nitride Electrodes Enables Culture and Physiological Recording of Electrogenic Cells.Frontiers in neuroscience · 2020Article
- Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis.Scientific reports · 2019Article
- Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type.Journal of neural engineering · 2018Article
- Temporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis.Scientific reports · 2018Article
- Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation.Journal of neurophysiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal degeneration (rd) leads to progressive photoreceptor cell death, resulting in vision loss. Stimulation of the inner-retinal neurons by neuroprosthetic implants is one of the clinically approved vision-restoration strategies, providing basic visual percepts to blind patients. However, little is understood as to what degree the degenerating retinal circuitry and the resulting aberrant hyperactivity may prevent the stimulation of physiological electrical activity. Therefore, we electrically stimulated ex vivo retinas from wild-type (wt; C57BL/6J) and blind (rd10 and rd1) mice using an implantable subretinal microchip and simultaneously recorded and analyzed the retinal ganglion cell (RGC) output with a flexible microelectrode array. We found that subretinal anodal stimulation of the rd10 retina and wt retina evoked similar spatiotemporal RGC-spiking patterns. In both retinas, electrically stimulated ON and a small percentage of OFF RGC responses were detected. The spatial selectivity of the retinal network to electrical stimuli reveals an intact underlying network with a median receptive-field center of 350 μm in both retinas. An antagonistic surround is activated by stimulation with large electrode fields. However, in rd10 and to a higher percentage, in rd1 retinas, rhythmic and spatially unconfined RGC patterns were evoked by anodal or by cathodal electrical stimuli. Our findings demonstrate that the surviving retinal circuitry in photoreceptor-degenerated retinas is preserved in a way allowing for the stimulation of temporally diverse and spatially confined RGC activity. Future vision restoration strategies can build on these results but need to avoid evoking the easily inducible rhythmic activity in some retinal circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.