ArticleProceedings of the National Academy of Sciences of the United States of America1989
Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- PVT1: a rising star among oncogenic long noncoding RNAs.BioMed research international · 2015Review
- The 8q24 gene desert: an oasis of non-coding transcriptional activity.Frontiers in genetics · 2012Article
- Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Molecular and cellular biology · 2010Article
- What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas.Leukemia · 2002Review
- The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene.Journal of virology · 2002Article
- The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.Journal of virology · 2000Article
- Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family.Journal of virology · 2000Article
- Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemia.Oncogene · 1999Article
- The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Phenotypes of murine leukemia virus-induced tumors: influence of 3' viral coding sequences.Journal of virology · 1992Article
- Molecular analysis of the aberrant replication banding pattern on chromosome 15 in murine T-cell lymphomas.Chromosoma · 1992Article
- Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.Journal of virology · 1991Article
- Evi-2, a common integration site involved in murine myeloid leukemogenesis.Molecular and cellular biology · 1990Article
- Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications.Journal of virology · 1990Article
- Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus.Journal of virology · 1990Article
- Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Mlvi-1/mis-1/pvt-1 locus, located approximately 270 kilobase pairs 3' of the c-myc protooncogene, was originally discovered as a common region of provirus integration in Moloney murine leukemia virus-induced rat T-cell lymphomas. The same locus was shown subsequently to be coamplified with c-myc and to be involved in chromosomal translocations in a variety of human and animal neoplasms. Provirus integration in Mlvi-1 in Moloney murine leukemia virus-induced rat T-cell lymphomas activates the c-myc protooncogene. The studies reported here were aimed to determine whether, in addition to the activation of c-myc, provirus integration affected the expression of other neighboring genes. Provirus integration was shown to occur in three clusters separated by regions of uninterrupted DNA. The proviruses in all three clusters had integrated in a single-transcriptional orientation, and they appeared intact. Systematic hybridization of Mlvi-1 clones to rat, mouse, and human genomic DNA revealed three patches of evolutionarily conserved sequences. Two of them were mapped in regions targeted by the provirus, and the third was mapped immediately 5' to the provirus clusters. A probe derived from the conserved sequences 5' of the integrated proviruses detected a tumor-specific RNA transcript in tumors carrying a provirus in Mlvi-1 or in the neighboring Mlvi-4 and c-myc loci. The highest level of RNA transcript expression, however, was seen in a CD4+ CD8+ tumor cell line that was not carrying a provirus in this region. We conclude that provirus insertion in this region activates both c-myc and another gene that is located in the immediate vicinity of the integrated Mlvi-1 proviruses and may be developmentally regulated in T cells.
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