ArticleScientific reports2016
Genome-wide association study of aggressive behaviour in chicken.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Genome-Wide Association Studies Reveal Key Candidate Genes for Egg Weight and Quality Components in an FVeterinary sciences · 2026Article
- Chemogenetic activation of the amygdala core nucleus increases aggression in chickens.iScience · 2026Article
- Development of a comprehensive GWAS atlas for chicken breeds.BMC bioinformatics · 2026Article
- Genetic Signatures of Competitive Performance in Burmese Gamecocks: A Transcriptomic Analysis.Biology · 2025Article
- Aggressive Mating Behavior in Roosters (Life (Basel, Switzerland) · 2025Review
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- Transcriptomic and metabolomic analysis based on different aggressive pecking phenotype in duck.Scientific reports · 2024Article
- Investigating the genetic determination of duration-of-fertility trait in breeding hens.Scientific reports · 2024Article
- Identify Candidate Genes Associated with the Weight and Egg Quality Traits in Wenshui Green Shell-Laying Chickens by the Copy Number Variation-Based Genome-Wide Association Study.Veterinary sciences · 2024Article
- Heat stress and poultry production: a comprehensive review.Poultry science · 2023Review
- Effects of Genotype and Housing System on Rabbit Does' Aggressive Behaviors and Injuries in Smallholding Conditions.Animals : an open access journal from MDPI · 2023Article
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- Epigenetics and the city: Non-parallel DNA methylation modifications across pairs of urban-forest Great tit populations.Evolutionary applications · 2022Article
- Population Genomic Sequencing Delineates Global Landscape of Copy Number Variations that Drive Domestication and Breed Formation of in Chicken.Frontiers in genetics · 2022Article
- A genome-wide scan to identify signatures of selection in two Iranian indigenous chicken ecotypes.Genetics, selection, evolution : GSE · 2021Article
- Mitochondrial polymorphism shapes intrapopulation behavioural variation in wildBiology letters · 2021Article
- SorCS2 is required for social memory and trafficking of the NMDA receptor.Molecular psychiatry · 2021Article
- Exploring the genetic architecture of feed efficiency traits in chickens.Scientific reports · 2021Article
- Genome diversity of Chinese indigenous chicken and the selective signatures in Chinese gamecock chicken.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the poultry industry, aggressive behaviour is a large animal welfare issue all over the world. To date, little is known about the underlying genetics of the aggressive behaviour. Here, we performed a genome-wide association study (GWAS) to explore the genetic mechanism associated with aggressive behaviour in chickens. The GWAS results showed that a total of 33 SNPs were associated with aggressive behaviour traits (P < 4.6E-6). rs312463697 on chromosome 4 was significantly associated with aggression (P = 2.10905E-07), and it was in the intron region of the sortilin-related VPS10 domain containing receptor 2 (SORCS2) gene. In addition, biological function analysis of the nearest 26 genes around the significant SNPs was performed with Ingenuity Pathway Analysis. An interaction network contained 17 genes was obtained and SORCS2 was involved in this network, interacted with nerve growth factor (NGF), nerve growth factor receptor (NGFR), dopa decarboxylase (L-dopa) and dopamine. After knockdown of SORCS2, the mRNA levels of NGF, L-dopa and dopamine receptor genes DRD1, DRD2, DRD3 and DRD4 were significantly decreased (P < 0.05). In summary, our data indicated that SORCS2 might play an important role in chicken aggressive behaviour through the regulation of dopaminergic pathways and NGF.
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