ArticleJournal of orthopaedic surgery and research2016
Effects of chronic sleep deprivation on bone mass and bone metabolism in rats.
Article in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03269760 (Advancing the Multimodal Pathway), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advancing the Multimodal Pathway: Investigating the Use of Sleep and Zolpidem in the Recovery After Shoulder Arthroplasty
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans.The Journal of clinical endocrinology and metabolism · 2017Trial
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Review
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- Correlation between occupational hazard exposure and abnormal bone mineral density in steelworkers.BMC public health · 2025Article
- Protective effect ofIranian journal of basic medical sciences · 2025Article
- Association Between Changes in Sleep, Nap Duration and Bone Mineral Density in Mexican Adults.Calcified tissue international · 2024Article
- Analysis of the relationship between shorter sleep duration and wrist fractures: based on NHANES.BMC musculoskeletal disorders · 2024Article
- Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations.Biomolecules · 2024Review
- Adherence to a healthy sleep pattern is associated with lower risks of incident falls and fractures during aging.Frontiers in immunology · 2023Article
- Bone Turnover Markers After Six Nights of Insufficient Sleep and Subsequent Recovery Sleep in Healthy Men.Calcified tissue international · 2022Article
- Sleep Disruption and Bone Health.Current osteoporosis reports · 2022Review
- High Prevalence of Sleep Disturbance Is Associated with Femoroacetabular Impingement Syndrome.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats.Frontiers in immunology · 2022Article
- Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women.Frontiers in nutrition · 2022Article
- Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Down-Regulated PI3K/AKT Signaling in Bone Tissues.Nature and science of sleep · 2022Article
- Association of short sleep duration and trabecular bone score.Scientific reports · 2021Article
- Contemporary Variables that Impact Sleep and Development in Female Adolescent Swimmers and Gymnasts.Sports medicine - open · 2021Review
- Sleep duration and bone health measures in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats.
methodsTwenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol (E2), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium.
resultsCompared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05).
conclusionsCSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.