ArticleFuture medicinal chemistry2016
Chemoinformatic expedition of the chemical space of fungal products.
Article in Future medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant-Associated Fungi.Phytochemical analysis : PCA · 2025Article
- Investigating and Quantifying Molecular Complexity Using Assembly Theory and Spectroscopy.ACS central science · 2024Article
- Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae.The Journal of antibiotics · 2023Article
- Oxetanes in Drug Discovery Campaigns.Journal of medicinal chemistry · 2023Review
- Diversity and Chemical Space Characterization of Inhibitors of the Epigenetic Target G9a: A Chemoinformatics Approach.ACS omega · 2023Article
- Scaffold and Structural Diversity of the Secondary Metabolite Space of Medicinal Fungi.ACS omega · 2023Article
- Discovery of Anticancer Agents of Diverse Natural Origin.Journal of natural products · 2022Article
- Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library.Pharmaceutics · 2022Article
- Three diketomorpholines from a Penicillium sp. (strain G1071).Phytochemistry · 2021Article
- Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations.Journal of natural products · 2021Article
- FragNet, a Contrastive Learning-Based Transformer Model for Clustering, Interpreting, Visualizing, and Navigating Chemical Space.Molecules (Basel, Switzerland) · 2021Article
- Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments.Journal of natural products · 2021Article
- Finding Constellations in Chemical Space Through Core Analysis.Frontiers in chemistry · 2019Article
- Media studies to enhance the production of verticillins facilitated by in situ chemical analysis.Journal of industrial microbiology & biotechnology · 2018Article
- Analysis of a large food chemical database: chemical space, diversity, and complexity.F1000Research · 2018Article
- Cheminformatic characterization of natural products from Panama.Molecular diversity · 2017Article
- Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites.Bioorganic & medicinal chemistry · 2017Article
- Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Journal of natural products · 2017Article
- Screening and identification of novel biologically active natural compounds.F1000Research · 2017Review
- Scaffold Diversity of Fungal Metabolites.Frontiers in pharmacology · 2017Article
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
9 authors.
Funding
Abstract
aimFungi are valuable resources for bioactive secondary metabolites. However, the chemical space of fungal secondary metabolites has been studied only on a limited basis. Herein, we report a comprehensive chemoinformatic analysis of a unique set of 207 fungal metabolites isolated and characterized in a USA National Cancer Institute funded drug discovery project.
resultsComparison of the molecular complexity of the 207 fungal metabolites with approved anticancer and nonanticancer drugs, compounds in clinical studies, general screening compounds and molecules Generally Recognized as Safe revealed that fungal metabolites have high degree of complexity. Molecular fingerprints showed that fungal metabolites are as structurally diverse as other natural products and have, in general, drug-like physicochemical properties.
conclusionFungal products represent promising candidates to expand the medicinally relevant chemical space. This work is a significant expansion of an analysis reported years ago for a smaller set of compounds (less than half of the ones included in the present work) from filamentous fungi using different structural properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.