Evidence map›Paper›PMID 27485509›Full record

Trial reportBMC health services research2016

Intervention to Improve Quality of life for African-AmericaN lupus patients (IQAN): study protocol for a randomized controlled trial of a unique a la carte intervention approach to self-management of lupus in African Americans.

Edith M Williams, Kate Lorig, Saundra Glover, Diane Kamen, Sudie Back, Anwar Merchant, Jiajia Zhang, James C Oates

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC health services research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01837875 (Intervention to Improve Quality of Life for African-AmericaN Lupus Patients), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01837875 nacompletednot on this map

Intervention to Improve Quality of Life for African-AmericaN Lupus Patients (IQAN)

TypeinterventionalSponsorMedical University of South CarolinaRan2013 to 2016Enrolled153ConditionsDepression, Systemic Lupus ErythematosusArmsChronic Disease Self-Management Program (CDSMP), Mail-delivered arthritis kit, Support group, Listserv
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Lupus nephritis.Nature reviews. Disease primers · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Edith M WilliamsDepartment of Public Health Sciences, Department of Medicine, Division of Rheumatology, Core Investigator, MUSC Center for Health Disparities Research, Medical University of South Carolina, 135 Cannon Street, Suite 303, MSC835, Charleston, SC, 29425, USA. wiled@musc.edu.
Kate LorigDepartment of Medicine, Stanford University, 291 Campus Drive, Room LK3C02, Stanford, CA, 94305, USA.
Saundra GloverInstitute of Health Disparities, University of South Carolina, 220 Stoneridge Drive, Suite 103, Columbia, SC, 29210, USA.
Diane KamenDepartment of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC, 29425, USA.
Sudie BackDepartment of Psychiatry/Behavioral Science, Division of Clinical Neuroscience, Medical University of South Carolina, 67 President Street, Charleston, SC, 29425, USA.
Anwar MerchantDepartment of Epidemiology and Biostatistics, University of South Carolina, 800 Sumter Street, Room 211, Columbia, SC, 29208, USA.
Jiajia ZhangDepartment of Epidemiology and Biostatistics, University of South Carolina, 915 Greene Street, Columbia, SC, 29208, USA.
James C OatesDepartment of Medicine, Division of Rheumatology, Medical University of South Carolina, 114 Doughty Street, Room 425-C, Charleston, SC, 29414, USA.
Medical University of South Carolina · USUniversity of South Carolina · USStanford University · USUniversity of South Carolina Sumter · US

Funding

Patient Resource CoreP60AR062755 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GILKESON, GARY S · 2012 to 2016
$5.8M
Intervention to Improve Quality of Life for African-American Lupus Patients (IQAN)K01AR060026 · NIAMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILLIAMS, EDITH MARIE · 2012 to 2015
$448k
NIAMS NIH HHS K01 AR060026NIAMS NIH HHS P60 AR062755
6 · The paper itself

Abstract

backgroundSystemic Lupus Erythematosus (lupus) is a chronic autoimmune disease that can impact any organ system and result in life-threatening complications. African-Americans are at increased risk for morbidity and mortality from lupus. Self-management programs have demonstrated significant improvements in health distress, self-reported global health, and activity limitation among people with lupus. Despite benefits, arthritis self-management education has reached only a limited number of people. Self-selection of program could improve such trends. The aim of the current study is to test a novel intervention to improve quality of life, decrease indicators of depression, and reduce perceived and biological indicators of stress in African-American lupus patients in South Carolina. METHODS/

designIn a three armed randomized, wait list controlled trial, we will evaluate the effectiveness of a patient-centered 'a-la-carte' approach that offers subjects a variety of modes of interaction from which they can choose as many or few as they wish, compared to a 'set menu' approach and usual care. This unique 'a-la-carte' self-management program will be offered to 50 African-American lupus patients participating in a longitudinal observational web-based SLE Database at the Medical University of South Carolina. Each individualized intervention plan will include 1-4 options, including a mail-delivered arthritis kit, addition and access to an online message board, participation in a support group, and enrollment in a local self-management program. A 'set menu' control group of 50 lupus patients will be offered a standardized chronic disease self-management program only, and a control group of 50 lupus patients will receive usual care. Outcomes will include changes in (a) health behaviors, (b) health status, (c) health care utilization, and (d) biological markers (urinary catecholamines). DISCUSSION: Such a culturally sensitive educational intervention which includes self-selection of program components has the potential to improve disparate trends in quality of life, disease activity, depression, and stress among African-American lupus patients, as better outcomes have been documented when participants are able to choose/dictate the content and/or pace of the respective treatment/intervention program. Since there is currently no "gold standard" self-management program specifically for lupus, this project may have a considerable impact on future research and policy decisions.

trial registrationNCT01837875 ; April 18, 2013.

Indexed as

AdultBlack or African AmericanChronic DiseaseDelivery of Health CareFemaleHealth BehaviorHealth StatusHumansLupus Erythematosus, SystemicMaleQuality of LifeSelf CareSouth CarolinaUnited StatesAfrican-AmericanLupusQuality of lifeRandomized trialSelf-management

Identifiers

PMID27485509
PMCPMC4971708
OpenAlexW2505604041

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.