ArticleThe Journal of infectious diseases2016
Renal Impairment and Cardiovascular Disease in HIV-Positive Individuals: The D:A:D Study.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Pooled it
- Differences in emergency department visit characteristics and resource utilization for persons with human immunodeficiency virus, 2018-2019 compared with 2009-2010.BMC emergency medicine · 2025Article
- Challenges of HIV Management in an Aging Population.Current HIV/AIDS reports · 2024Review
- Advances in the Management of Cardiovascular Disease in the Setting of Human Immunodeficiency Virus.Infectious disease clinics of North America · 2024Review
- Clinical characteristics of women with HIV in the RESPOND cohort: A descriptive analysis and comparison to men.HIV medicine · 2024Article
- Cardiac and Renal Comorbidities in Aging People Living With HIV.Circulation research · 2024Review
- Article
- Predicting cardiovascular risk using a novel risk score in young and middle-age adults with HIV: associations with biomarkers and carotid atherosclerotic plaque.International journal of STD & AIDS · 2022Article
- Effects of HIV Infection on Arterial Endothelial Function: Results From a Large Pooled Cohort Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Risks of cardio-vascular diseases among highly active antiretroviral therapy (HAART) treated HIV seropositive volunteers at a treatment centre in Lagos, Nigeria.The Pan African medical journal · 2021Article
- Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Factors associated to chronic kidney disease in people living with HIV/AIDS.Revista latino-americana de enfermagem · 2020Article
- HIV infection and coronary heart disease: mechanisms and management.Nature reviews. Cardiology · 2019Review
- Predictors of Ischemic and Hemorrhagic Strokes Among People Living With HIV: The D:A:D International Prospective Multicohort Study.EClinicalMedicine · 2019Article
- Observational
- Mild renal impairment is associated with calcified plaque parameters assessed by computed tomography angiography in people living with HIV.AIDS (London, England) · 2019Article
- Observational
- Serious Non-AIDS Conditions in HIV: Benefit of Early ART.Current HIV/AIDS reports · 2018Review
- Hepatitis C virus cure does not impact kidney function decline in HIV co-infected patients.AIDS (London, England) · 2018Observational
- Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda.BMJ open · 2018Observational
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 8 countries.
Funding
Abstract
backgroundWhile the association between renal impairment and cardiovascular disease (CVD) is well established in the general population, the association remains poorly understood in human immunodeficiency virus (HIV)-positive individuals.
methodsIndividuals with ≥2 estimated glomerular filtration rate (eGFR) measurements after 1 February 2004 were followed until CVD, death, last visit plus 6 months, or 1 February 2015. CVD was defined as the occurrence of centrally validated myocardial infarction, stroke, invasive cardiovascular procedures, or sudden cardiac death.
resultsDuring a median follow-up duration of 8.0 years (interquartile range, 5.4-8.9 years) 1357 of 35 357 individuals developed CVD (incidence rate, 5.2 cases/1000 person-years [95% confidence interval {CI}, 5.0-5.5]). Confirmed baseline eGFR and CVD were closely related with 1.8% of individuals (95% CI, 1.6%-2.0%) with an eGFR > 90 mL/minute/1.73 m(2) estimated to develop CVD at 5 years, increasing to 21.1% (95% CI, 6.6%-35.6%) among those with an eGFR ≤ 30 mL/minute/1.73 m(2) The strong univariate relationship between low current eGFR and CVD was primarily explained by increasing age in adjusted analyses, although all eGFRs ≤ 80 mL/minute/1.73 m(2) remained associated with 30%-40% increased CVD rates, and particularly high CVD rates among individuals with an eGFR ≤ 30 mL/minute/1.73 m(2) (incidence rate ratio, 3.08 [95% CI, 2.04-4.65]).
conclusionsAmong HIV-positive individuals in a large contemporary cohort, a strong relation between confirmed impaired eGFR and CVD was observed. This finding highlights the need for renal preventive measures and intensified monitoring for emerging CVD, particularly in older individuals with continuously low eGFRs.
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Registered trials
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