ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Clinical significance of β2-adrenergic receptor expression in patients with surgically resected gastric adenocarcinoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- β-Blockers Influence Oncological Outcomes in Gastric Cancer Patients Treated with Neoadjuvant Chemotherapy Based on the Pathological Subtype: A Retrospective Cohort Study.Annals of surgical oncology · 2025Article
- Invited Editorial About: "Impact of Tumoral β2-Adrenergic Receptor Expression on Chemotherapeutic Response and Prognosis in Patients with Advanced Colorectal Cancer," by C. Komine et al.Annals of surgical oncology · 2025Article
- Impact of Tumoral β2-Adrenergic Receptor Expression on Chemotherapeutic Response and Prognosis in Patients with Advanced Colorectal Cancer.Annals of surgical oncology · 2025Article
- Transcriptome sequencing identifies prognostic genes involved in gastric adenocarcinoma.Molecular and cellular biochemistry · 2023Article
- ADRB2 expression predicts the clinical outcomes and is associated with immune cells infiltration in lung adenocarcinoma.Scientific reports · 2022Article
- Review
- Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer.Translational oncology · 2021Article
- Assessment of Epinephrine and Norepinephrine in Gastric Carcinoma.International journal of molecular sciences · 2021Article
- Non-coding RNAs underlying chemoresistance in gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2020Review
- Prognostic significance of β2-adrenergic receptor expression in patients with surgically resected colorectal cancer.International journal of clinical oncology · 2020Article
- Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- β2-AR regulates the expression of AKR1B1 in human pancreatic cancer cells and promotes their proliferation via the ERK1/2 pathway.Molecular biology reports · 2018Article
- The role of propranolol as a radiosensitizer in gastric cancer treatment.Drug design, development and therapy · 2018Article
- Identification of aberrantly expressed long non-coding RNAs in stomach adenocarcinoma.Oncotarget · 2017Article
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11 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The β2-adrenergic receptor (β2-AR) is highly expressed in various human neoplasms and has been considered a novel therapeutic target of cancer treatment. However, the clinicopathological significance of β2-AR expression in patients with gastric cancer (GC) remains unclear. The aim of this study was to explore β2-AR expression and its prognostic significance. A total of 331 patients with surgically resected GC were evaluated. Tumor sections were stained immunohistochemically for β2-AR. And, we confirmed β2-AR expression in the GC cell lines by Western blot. β2-AR was highly expressed in 30.5 % of GC patients. Expression was significantly associated with age, T factor, tumor differentiation, histology of non-signet cells, lymphatic permeation, and vascular invasion. And, all the GC cell lines expressed β2-AR. On univariate analysis, age, disease stage, T factor, N factor, lymphatic permeation, vascular invasion, and β2-AR expression were significantly associated with overall survival. Although the multivariate analysis did not indicate that β2-AR expression was independently prognostic of survival, high-level β2-AR expression was associated with significantly poorer survival of GC patients with well or moderately differentiated tumors. β2-AR expression was a significant predictor of tumor aggressiveness in, and poorer survival of, patients with GC.
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