SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2016
Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.
- Clinical relevance of intraoperative blood loss in pancreatic surgery: a systematic review and meta-analysis to reappraise the impact on post operative pancreatic fistula.Langenbeck's archives of surgery · 2025Pooled it
- Continuous irrigation after pancreatectomy: a systematic review.Langenbeck's archives of surgery · 2023Pooled it
- Efficacy of rectal indomethacin in prevention of post-operative hyperamylasemia following pancreatoduodenectomy: a randomized controlled trial.Langenbeck's archives of surgery · 2023Trial
- Trial
- Randomized clinical trial of the effect of a fibrin sealant patch on pancreatic fistula formation after pancreatoduodenectomy.The British journal of surgery · 2018Trial
- Development and validation of a preoperative CT-based radiomics nomogram for predicting postpancreatectomy acute pancreatitis after pancreatoduodenectomy.Abdominal radiology (New York) · 2026Article
- Clinical Evaluation of Postoperative Day 3 Serum Lipase in Relation to Clinically Relevant Pancreatic Fistula After Distal Pancreatectomy: A Retrospective Cohort Study.Biomedicines · 2026Article
- Optimal Timing of Serum Lipase for Early Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy.Cancers · 2026Article
- FulminantAnnals of hepato-biliary-pancreatic surgery · 2026Article
- Postoperative hyperamylasemia-an early warning signal after distal pancreatectomy.Hepatobiliary surgery and nutrition · 2026Article
- Surgical Procedures Used in the Treatment of Postoperative Acute Pancreatitis Grade C After Pancreatoduodenectomy-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- "The Critical 18" of postoperative white blood cell count and C-reactive protein level predicts postoperative pancreatic fistula after distal pancreatectomy.Patient safety in surgery · 2026Article
- Analysis of Different Post-Operative Hyperamylasemia Criteria for Defining Post-Pancreatectomy Acute Pancreatitis After Distal Pancreatectomy-A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Multiparameter pancreatic parenchyma assessment using Dual-layer Spectral-detector CT for postpancreatectomy acute pancreatitis prediction.Abdominal radiology (New York) · 2026Article
- Post-transplant acute pancreatitis after pancreas transplantation: application of the International Study Group for Pancreatic Surgery definition and clinical impact in a multicenter cohort study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Post-pancreatectomy acute pancreatitis (PPAP) - A global definition with variable regional recognition.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2025Article
- Postoperative Acute Pancreatitis After Pancreatic Resections-A Narrative Review and a Diagnostic Algorithm.Cancers · 2025Review
- Postpancreatectomy acute pancreatitis in pancreaticoduodenectomy and distal pancreatectomy: a retrospective cohort study on risk factors and clinical outcomes.Surgical endoscopy · 2025Article
- Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy: A retrospective cohort study.World journal of gastroenterology · 2025Article
- Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPost-operative pancreatic fistula has been well defined. However the underlying aetiology remains poorly understood. The aim of this review was to investigate whether the underlying aetiology for a proportion of patients suffering from post-operative pancreatic fistula was due to post-operative pancreatitis.
methodA systematic literature review according to the PRISMA guidelines. The date range was from 2005 to 2016. The search strategy included the terms: post-operative pancreatitis, pathophysiology, post-operative pancreatic fistula, pancreaticoduodenectomy, ischaemic pancreatitis, microcirculation and pancreatitis, serum and drain amylase and lipase. The data was summarised without quantitative or qualitative analysis.
resultsThere exists significant physiological, biochemical, clinical and histological evidence in the literature that a proportion of post-operative pancreatic fistula is due to post-operative pancreatitis. A new definition of post-operative pancreatitis based on the presence of biochemical evidence for pancreatic inflammation (urinary trypsinogen-2 >50 ug/L or serum amylase/lipase > upper limit of normal) between post-operative days 0-2. Predicted severity is based on C-reactive protein with a cut-off of 180 mg/L at post-operative day 2. The proposed grading of severity is in line with previous work by international study group of pancreatic surgery.
conclusionPost-operative pancreatitis should be recognised as a separate pancreatic specific complication following pancreatic resection. Improved recognition may allow better understanding of potential methods of prevention, treatment and prediction of severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.