SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2016
Positive para-aortic lymph nodes following pancreatectomy for pancreatic cancer. Systematic review and meta-analysis of impact on short term survival and association with clinicopathologic features.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of surgical resection of liver-only synchronous metastases from pancreatic cancer in the era of multiagent chemotherapy.Updates in surgery · 2020Pooled it
- Ferumoxtran-10-enhanced MRI for pre-operative metastatic lymph node detection in pancreatic, duodenal, or periampullary adenocarcinoma.European radiology · 2024Trial
- Article
- Prognostic Impact of Para-Aortic Lymph Node Metastasis in Resected Non-Pancreatic Periampullary Cancers.Annals of surgical oncology · 2024Article
- Pancreaticoduodenectomy with Para-aortic Lymph Node Dissection for Periampullary Cancer.Indian journal of surgical oncology · 2024Article
- Impact of para aortic lymph node removal on survival following resection for pancreatic adenocarcinoma.BMC surgery · 2023Article
- Article
- The prognostic relevance of examined lymph nodes for accurate staging of resected pancreatic adenocarcinoma.Hepatobiliary surgery and nutrition · 2022Article
- Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma.World journal of gastrointestinal surgery · 2022Article
- Korean Surgical Practice Guideline for Pancreatic Cancer 2022: A summary of evidence-based surgical approachesAnnals of hepato-biliary-pancreatic surgery · 2022Article
- Systemic Therapy for Metastatic Pancreatic Cancer.Current treatment options in oncology · 2021Review
- Clinical Impact of Unexpected Para-Aortic Lymph Node Metastasis in Surgery for Resectable Pancreatic Cancer.Cancers · 2021Article
- Impact of resection margin status on survival in advanced N stage pancreatic cancer - a multi-institutional analysis.Langenbeck's archives of surgery · 2021Article
- Role of lymphadenectomy in resectable pancreatic cancer.Langenbeck's archives of surgery · 2020Review
- Dilemmas for the pathologist in the oncologic assessment of pancreatoduodenectomy specimens : An overview of different grossing approaches and the relevance of the histopathological characteristics in the oncologic assessment of pancreatoduodenectomy specimens.Virchows Archiv : an international journal of pathology · 2018Review
- Para-aortic lymph node metastases in pancreatic cancer should not be considered a watershed for curative resection.Scientific reports · 2017Article
- Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer.World journal of gastroenterology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relation between para-aortic lymph nodes (PALN) involvement and pancreatic ductal adenocarcinoma (PDAC) survival, along with the optimal handling of this particular lymph node station remain unclear. A systematic review and meta-analysis was performed to assess this.
methodsA search of Medline, Embase, Ovid and Cochrane databases was performed until July 2015 to identify studies reporting on the relation of PALN involvement and PDAC outcomes and a meta-analysis was performed following data extraction.
resultsTen retrospective studies and two prospective non randomized studies (2467 patients) were included. Patients with positive PALN had worse one (p < 0.00001) and two year (p < 0.00001) survival when compared with patients with negative PALN. Even when comparing only patients with positive lymph nodes (N1), patients with PALN involvement presented with a significant lower one (p = 0.03) and two (p = 0.002) year survival. PALN involvement was associated with an increased possibility of positive margin (R1) resection (p < 0.00001), stations' 12, 14 and 17 malignant infiltration (p < 0.00001), but not with tumour stage (p = 0.78). DISCUSSION: Involvement of PALN is associated with decreased survival in pancreatic cancer patients. However, existence of long term survivors among this subgroup of patients should be further evaluated, in order to identify factors associated with their favourable prognosis.
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