Evidence map›Paper›PMID 27485050›Full record

Trial reportBMC pregnancy and childbirth2016

Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study.

Jennifer Anne Williams, Vivian C Romero, Chelsea M Clinton, Delia M Vazquez, Sheila M Marcus, Julie L Chilimigras, Susan E Hamilton, Lucy J Allbaugh, Anjel M Vahratian, Ronald M Schrader and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00711971 (Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00711971 phase2 / phase3completednot on this map

Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?

TypeinterventionalSponsorUniversity of MichiganRan2008 to 2013Enrolled126ConditionsDepressionArmsEPA-rich fish oil supplement, DHA-rich fish oil supplement, placebo
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  5. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
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  15. Review
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  18. Levels of 25-hydroxyvitamin DMetabolic brain disease · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jennifer Anne WilliamsDepartment of Obstetrics and Gynecology, St. Joseph Mercy Health System, Ypsilanti, MI, USA.
Vivian C RomeroSpectrum Health Maternal Fetal Medicine, Grand Rapids, MI, USA.
Chelsea M ClintonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Delia M VazquezDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Sheila M MarcusDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Julie L ChilimigrasDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Susan E HamiltonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Lucy J AllbaughDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Anjel M VahratianDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Ronald M SchraderClinical and Translational Science Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ellen L MozurkewichDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. emozurkewich@salud.unm.edu.
University of Michigan–Ann Arbor · USUniversity of New Mexico · USMercy Health System · USMichigan State University · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Does EPA or DHA prevent depressive symptoms in pregnancy and postpartum?R21AT004166 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOZURKEWICH, ELLEN · 2008 to 2011
$648k
NCATS NIH HHS UL1 TR000041NCCIH NIH HHS R21 AT004166NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

backgroundVitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy.

methodsThis study was a secondary analysis of a randomized trial designed to assess whether prenatal omega-3 fatty acid supplementation would prevent depressive symptoms. Pregnant women from Michigan who were at risk for depression based on Edinburgh Postnatal Depression Scale Score or history of depression were enrolled. Participants completed the Beck Depression Inventory (BDI) and Mini International Neuropsychiatric Interview at 12-20 weeks, 26-28 weeks, 34-36 weeks, and 6-8 weeks postpartum. Vitamin D levels were measured at 12-20 weeks (N = 117) and 34-36 weeks (N = 112). Complete datasets were available on 105 subjects. Using regression analyses, we evaluated the relationship between vitamin D levels with BDI scores as well as with MINI diagnoses of major depressive disorder and generalized anxiety disorder. Our primary outcome measure was the association of maternal vitamin D levels with BDI scores during early and late pregnancy and postpartum.

resultsWe found that vitamin D levels at 12-20 weeks were inversely associated with BDI scores both at 12-20 and at 34-36 weeks' gestation (P < 0.05, both). For every one unit increase in vitamin D in early pregnancy, the average decrease in the mean BDI score was .14 units. Vitamin D levels were not associated with diagnoses of major depressive disorder or generalized anxiety disorder.

conclusionsIn women at risk for depression, early pregnancy low vitamin D levels are associated with higher depressive symptom scores in early and late pregnancy. Future investigations should study whether vitamin D supplementation in early pregnancy may prevent perinatal depressive symptoms.

trial registrationhttps://clinicaltrials.gov/ REGISTRATION NUMBER: NCT00711971.

Indexed as

AdultDepressionDepression, PostpartumDietary SupplementsDouble-Blind MethodFatty Acids, Omega-3FemaleHumansMaternal Serum Screening TestsPostpartum PeriodPregnancyPregnancy ComplicationsPregnancy TrimestersPsychiatric Status Rating ScalesRegression AnalysisRisk Factors25-hydroxyvitamin DFatty Acids, Omega-3Vitamin DDepressionPregnancyVitamin D

Identifiers

PMID27485050
PMCPMC4971719
OpenAlexW2478958371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.