Evidence map›Paper›PMID 27485040›Full record

ArticleBrain, behavior, and immunity2016

β-Adrenergic-stimulated macrophages: Comprehensive localization in the M1-M2 spectrum.

Donald M Lamkin, Hsin-Yun Ho, Tiffany H Ong, Carly K Kawanishi, Victoria L Stoffers, Nivedita Ahlawat, Jeffrey C Y Ma, Jesusa M G Arevalo, Steve W Cole, Erica K Sloan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Mechanistic basis for the antifibrotic actions of cAMP-based therapies.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023
    Review
  14. Review
  15. Review
  16. Heme: The Lord of the Iron Ring.Antioxidants (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Nerves in gastrointestinal cancer: from mechanism to modulations.Nature reviews. Gastroenterology & hepatology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Donald M LamkinCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: dlamkin@ucla.edu.
Hsin-Yun HoCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Tiffany H OngCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Carly K KawanishiCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Victoria L StoffersCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Nivedita AhlawatCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Jeffrey C Y MaDivision of Hematology-Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Jesusa M G ArevaloDivision of Hematology-Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Steve W ColeCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA; Division of Hematology-Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Erica K SloanCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.
University of California, Los Angeles · USMonash University · AUNeurobehavioral Systems · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y. · 1991 to 2018
$39.9M
Social regulation of pro-inflammatory monocytesR01AG043404 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2014 to 2018
$1.6M
Adrenergic regulation of tumor inflammation and metastatic disseminationR01CA160890 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLOAN, ERICA KATE · 2012 to 2016
$1.6M
Translational Research of Biobehavioral Mechanisms in Cancer ControlK07CA188237 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAMKIN, DONALD MICHAEL · 2015 to 2019
$766k
NCI NIH HHS K07 CA188237NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA160890NIAID NIH HHS P30 AI028697NIA NIH HHS R01 AG043404
6 · The paper itself

Abstract

β-Adrenergic signaling can regulate macrophage involvement in several diseases and often produces anti-inflammatory properties in macrophages, which are similar to M2 properties in a dichotomous M1 vs. M2 macrophage taxonomy. However, it is not clear that β-adrenergic-stimulated macrophages may be classified strictly as M2. In this in vitro study, we utilized recently published criteria and transcriptome-wide bioinformatics methods to map the relative polarity of murine β-adrenergic-stimulated macrophages within a wider M1-M2 spectrum. Results show that β-adrenergic-stimulated macrophages did not fit entirely into any one pre-defined category of the M1-M2 spectrum but did express genes that are representative of some M2 side categories. Moreover, transcript origin analysis of genome-wide transcriptional profiles located β-adrenergic-stimulated macrophages firmly on the M2 side of the M1-M2 spectrum and found active suppression of M1 side gene transcripts. The signal transduction pathways involved were mapped through blocking experiments and bioinformatics analysis of transcription factor binding motifs. M2-promoting effects were mediated specifically through β2-adrenergic receptors and were associated with CREB, C/EBPβ, and ATF transcription factor pathways but not with established M1-M2 STAT pathways. Thus, β-adrenergic-signaling induces a macrophage transcriptome that locates on the M2 side of the M1-M2 spectrum but likely accomplishes this effect through a signaling pathway that is atypical for M2-spectrum macrophages.

Indexed as

Signal TransductionTranscriptomeAdrenergic beta-AgonistsAnimalsBone MarrowComputational BiologyFemaleIsoproterenolMacrophage ActivationMacrophagesMiceMice, Inbred BALB CReceptors, Adrenergic, beta-2Adrenergic beta-AgonistsIsoproterenolReceptors, Adrenergic, beta-2BioinformaticsCREBM1-M2 spectrumMacrophageTranscriptomeβ-Adrenergic

Identifiers

PMID27485040
PMCPMC5011037
OpenAlexW2505201035

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.