ArticleScientific reports2016
Synaptic Basis for the Generation of Response Variation in Auditory Cortex.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Spike Reliability is Cell-Type Specific and Shapes Excitation and Inhibition in the Cortex.bioRxiv : the preprint server for biology · 2024Article
- Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Measuring Synchronization between Spikes and Local Field Potential Based on the Kullback-Leibler Divergence.Computational intelligence and neuroscience · 2021Article
- Dendritic Spikes Expand the Range of Well Tolerated Population Noise Structures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Anterior Auditory Field Is Needed for Sound Categorization in Fear Conditioning Task of Adult Rat.Frontiers in neuroscience · 2019Article
- Temporal Coding of Voice Pitch Contours in Mandarin Tones.Frontiers in neural circuits · 2018Article
- Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat.Neural plasticity · 2018Article
- Diversity in Excitation-Inhibition Mismatch Underlies Local Functional Heterogeneity in the Rat Auditory Cortex.Cell reports · 2017Article
- Bidirectional Shifting Effects of the Sound Intensity on the Best Frequency in the Rat Auditory Cortex.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cortical neurons can exhibit significant variation in their responses to the same sensory stimuli, as reflected by the reliability and temporal precision of spikes. However the synaptic mechanism underlying response variation still remains unclear. Here, in vivo whole-cell patch-clamp recording of excitatory neurons revealed variation in the amplitudes as well as the temporal profiles of excitatory and inhibitory synaptic inputs evoked by the same sound stimuli in layer 4 of the rat primary auditory cortex. Synaptic inputs were reliably induced by repetitive stimulation, although with large variation in amplitude. The variation in the amplitude of excitation was much higher than that of inhibition. In addition, the temporal jitter of the synaptic onset latency was much smaller than the jitter of spike response. We further demonstrated that the amplitude variation of excitatory inputs can largely account for the spike variation, while the jitter in spike timing can be primarily attributed to the temporal variation of excitatory inputs. Furthermore, the spike reliability of excitatory but not inhibitory neurons is dependent on tone frequency. Our results thus revealed an inherent cortical synaptic contribution for the generation of variation in the spike responses of auditory cortical neurons.
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