Evidence map›Paper›PMID 27484805›Full record

ArticleBMC cancer2016

Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer.

Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo, Nagara Tamaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Influences on PET Quantification and Interpretation.Diagnostics (Basel, Switzerland) · 2022
    Review
  8. Article
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  11. Review
  12. Article
  13. Article
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  15. Article
  16. Influence on [EJNMMI research · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomoka KitaoRadiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, Sapporo, 003-0804, Japan.
Kenji HirataDepartment of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan. khirata@med.hokudai.ac.jp.
Katsumi ShimaRadiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, Sapporo, 003-0804, Japan.
Takashi HayashiRadiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, Sapporo, 003-0804, Japan.
Mitsunori SekizawaRadiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, Sapporo, 003-0804, Japan.
Toshiki TakeiDepartment of Diagnostic Radiology, Hokkaido Cancer Center, Sapporo, Japan.
Wataru IchimuraDepartment of Diagnostic Radiology, Hokkaido Cancer Center, Sapporo, Japan.
Masao HaradaDepartment of Respiratory Medicine, Hokkaido Cancer Center, Sapporo, Japan.
Keishi KondoDepartment of Thoracic Surgery, Hokkaido Cancer Center, Sapporo, Japan.
Nagara TamakiDepartment of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time.

methodsFifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTVp and TLGp; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTVq% and TLGq%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTVARG and TLGARG). Parameters were compared between operators and between phases.

resultsBoth the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV3.0 and MTV3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV2.0 and MTV2.5 neither increased nor decreased (P = n.s.). All of the MTVq% values significantly decreased over time (P < 0.01), whereas MTVARG and TLG with any delineation method increased significantly (P < 0.05).

conclusionsHigh reproducibility of MTV and TLG was obtained by all of the methods used. MTV2.0 and MTV2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.

Indexed as

AgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleFluorodeoxyglucose F18GlycolysisHumansLung NeoplasmsMaleMiddle AgedObserver VariationPositron-Emission TomographyPrognosisRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesFluorodeoxyglucose F18RadiopharmaceuticalsFDG-PETLung cancerMetabolic tumor volumeReproducibilityTotal lesion glycolysis

Identifiers

PMID27484805
PMCPMC4969656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.