Evidence map›Paper›PMID 27484767›Full record

ArticleChinese journal of integrative medicine2017

Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.

Chun-Hung Yang, Heng-Yuan Chang, Yi-Chuan Chen, Chia-Chen Lu, Shyh-Shyun Huang, Guan-Jhong Huang, Hsin-Chih Lai

Abstract read
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In one paragraph

Article in Chinese journal of integrative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Food science & nutrition · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chun-Hung YangGraduate Institute of Biomedical Science, Division of Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, 333, Taiwan, Republic of China.
Heng-Yuan ChangSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan, 970, China.
Yi-Chuan ChenSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan, 970, China.
Chia-Chen LuGraduate Institute of Biomedical Science, Division of Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, 333, Taiwan, Republic of China.
Shyh-Shyun HuangSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan, 404, China.
Guan-Jhong HuangSchool of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan, 404, China. gjhuang@mail.cmu.edu.tw.
Hsin-Chih LaiGraduate Institute of Biomedical Science, Division of Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, 333, Taiwan, Republic of China. hclai@mail.cgu.edu.tw.
Chang Gung University · TWChina Medical University · TWTzu Chi University · TWFu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study whether the ethanol extract of Phellinus merrillii (EPM) has chemopreventive potential against liver carcinogenesis.

methodsThirty male Spraque-Dawley rats were randomly divided into control group, EPM control group, hepatocarcinoma control group, low-dose EPM group and high-dose EPM group, 6 in each group. Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated. Basic pathophysiological and histological examinations, together with the serum levels of glutamic oxaloacetic transaminase (sGOT), glutamic pyruvic transaminase (sGPT) and gamma-glutamyl transpeptidase (γ-GT) were measured.

resultsTreatment of EPM at the concentration of 2 g/kg body weight in the diet for 8 weeks clearly prevented the development of carcinogenesis and reduced the levels of sGOT, sGPT, and serum γ-GT of rats as compared with the hepatocarcinoma control group (P<0.05 or P<0.01). These phenotypes were accompanied by a significant increase in natural killer cell activity.

conclusionEPM showed a strong liver preventive effect against DEN+2-AAF+PH-induced hepatocarcinogenesis in a rat model.

Indexed as

2-AcetylaminofluoreneDiethylnitrosamineAnimalsBasidiomycotaCarcinogenesisCytoprotectionEthanolLiver Neoplasms, ExperimentalMalePhellinusPlant ExtractsProtective AgentsRatsRats, Sprague-Dawley2-AcetylaminofluoreneDiethylnitrosamineEthanolPhellinus linteus extractPlant ExtractsProtective Agents2-acetylaminofluorenechemopreventiondiethylnitrosaminehepatocarcinogenesisPhellinus merrillii

Identifiers

PMID27484767
OpenAlexW2492472879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.