ArticleAngewandte Chemie (International ed. in English)2016
Unraveling the Thermodynamics of the Folding and Interconversion of Human Telomere G-Quadruplexes.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Unraveling G-Quadruplex and i-Motif Coexistence Within a Double-Stranded DNA.Angewandte Chemie (International ed. in English) · 2026Article
- Structural basis of G-quadruplex recognition by a camelid antibody fragment.Nucleic acids research · 2025Article
- G-Quadruplexes in Tumor Immune Regulation: Molecular Mechanisms and Therapeutic Prospects in Gastrointestinal Cancers.Biomedicines · 2025Review
- Early events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering.Nucleic acids research · 2025Article
- Early Events in G-quadruplex Folding Captured by Time-Resolved Small-Angle X-Ray Scattering.bioRxiv : the preprint server for biology · 2024Article
- Thermodynamic Origin of the Linear Pressure Dependence of DNA Thermal Stability.The journal of physical chemistry letters · 2024Article
- Insect multimeric G-quadruplexes fold into antiparallel structures of different compactness and stability in KRSC advances · 2023Article
- Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Polymorphic and Higher-Order G-Quadruplexes as Possible Transcription Regulators: Novel Perspectives for Future Anticancer Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Thermodynamic Stability of G-Quadruplexes: Impact of Sequence and Environment.Chembiochem : a European journal of chemical biology · 2021Review
- Volumetric Properties of Four-Stranded DNA Structures.Biology · 2021Review
- BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.Nucleic acids research · 2020Article
- Studying biomolecular folding and binding using temperature-jump mass spectrometry.Nature communications · 2020Article
- Fundamentals of G-quadruplex biology.Annual reports in medicinal chemistry · 2020Article
- Parallel G-triplexes and G-hairpins as potential transitory ensembles in the folding of parallel-stranded DNA G-Quadruplexes.Nucleic acids research · 2019Article
- Towards Understanding of Polymorphism of the G-rich Region of Human Papillomavirus Type 52.Molecules (Basel, Switzerland) · 2019Article
- Solution Structure of aACS omega · 2019Article
- Polymorphism of G4 associates: from stacks to wires via interlocks.Nucleic acids research · 2018Article
- Structural dynamics of propeller loop: towards folding of RNA G-quadruplex.Nucleic acids research · 2018Article
- Stability of the NaACS omega · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Why human telomere DNA fragments fold into different G-quadruplex structures with parallel, hybrid, and antiparallel strand orientations depending on the temperature and concentration of co-solutes remains poorly understood. Similarly, the formation of intermediate structures along the folding or interconversion pathways is not well understood. Herein, we address these questions by introducing a conceptual framework, based on the global thermodynamic analysis of DSC and CD spectroscopy data, which led to a detailed description of the topological phase space (phase diagram) of the stability of the human telomere fragment 5'-AGGG(TTAGGG)3 -3' (Tel22). This framework clarifies the driving forces of quadruplex folding and interconversion processes over a wide range of temperatures and ion (K(+) , Na(+) ) and polyethylene glycol (PEG) concentrations and demonstrates their linkage to the human telomere DNA structural features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.