ArticleImmunogenetics2017
Preferred SLA class I/class II haplotype combinations in German Landrace pigs.
Article in Immunogenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Immunopeptidomics ofBiology · 2024Article
- Comparative analysis of swine leukocyte antigen gene diversity in Göttingen Minipigs.Frontiers in immunology · 2024Article
- Potential SLA Hp-4.0 haplotype-restricted CTL epitopes identified from the membrane protein of PRRSV induce cell immune responses.Frontiers in microbiology · 2024Article
- Comparative analysis of swine leukocyte antigen gene diversity in European farmed pigs.Animal genetics · 2021Article
- Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations.Frontiers in veterinary science · 2021Article
- Article
- Analysis of swine leukocyte antigen class I gene profiles and porcine endogenous retrovirus viremia level in a transgenic porcine herd inbred for xenotransplantation research.Journal of veterinary science · 2018Article
- Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC genes, as observed in humans, are believed to serve the evolutionary goal to achieve a high genetic diversity, allowing for a broad and efficient immune response. In a cohort of 155 pedigreed German Landrace pigs (65 founders and 90 piglets), we found that MHC genes occur in particular class I and class II haplotype combinations. This phenomenon has not been described before, probably because most of the earlier MHC studies in pigs were not pedigree-based. After comparing our data with published genotypes of different European pig breeds and Asian pigs, we hypothesise that the combination of particular but different haplotypes in different geographical regions may have developed under the evolutionary pressure of regionally endemic pathogens. This proposed mechanism ensures an efficient immune response despite low recombination rates.
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Registered trials
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