ArticleBiogerontology2016
Repurposing FDA-approved drugs for anti-aging therapies.
Article in Biogerontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
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- "Post-Protean" Public Health and the Geroscience Hypothesis.Aging and disease · 2024Article
- Imagination and idealism after the COVID-19 pandemic: the science of healthy ageing.Royal Society open science · 2024Article
- Longevity Science and Women's Health and Wellbeing.Journal of population ageing · 2023Article
- We are all aging, and here's why.Aging medicine (Milton (N.S.W)) · 2022Review
- Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes.Biology · 2022Review
- Repurposing FDA-Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease.ChemistryOpen · 2021Article
- Article
- Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging.Nutrition and healthy aging · 2021Review
- High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.Science advances · 2020Article
- Potential Role of Cellular Senescence in Asthma.Frontiers in cell and developmental biology · 2020Review
- Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans.Nature communications · 2019Article
- Identifying Potential Ageing-Modulating Drugs In Silico.Trends in endocrinology and metabolism: TEM · 2019Review
- Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature.Experimental gerontology · 2018Article
- Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.Biogerontology · 2018Article
- Aging extension and modifications of lipid metabolism in the monogonont rotifer Brachionus koreanus under chronic caloric restriction.Scientific reports · 2018Article
- Drug repurposing for aging research using model organisms.Aging cell · 2017Article
- The conundrums of chronic kidney disease and aging.Journal of nephrology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There is great interest in drugs that are capable of modulating multiple aging pathways, thereby delaying the onset and progression of aging. Effective strategies for drug development include the repurposing of existing drugs already approved by the FDA for human therapy. FDA approved drugs have known mechanisms of action and have been thoroughly screened for safety. Although there has been extensive scientific activity in repurposing drugs for disease therapy, there has been little testing of these drugs for their effects on aging. The pool of FDA approved drugs therefore represents a large reservoir of drug candidates with substantial potential for anti-aging therapy. In this paper we employ FINDSITE
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.