Evidence map›Paper›PMID 27484129›Full record

ArticleBMC geriatrics2016

Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity.

Leiv Otto Watne, Ane-Victoria Idland, Durk Fekkes, Johan Raeder, Frede Frihagen, Anette Hylen Ranhoff, Farrukh Abbas Chaudhry, Knut Engedal, Torgeir Bruun Wyller, Bjørnar Hassel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Leiv Otto WatneInstitute of Clinical Medicine, University of Oslo, Oslo, Norway. l.o.watne@gmail.com.
Ane-Victoria IdlandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Durk FekkesDepartment of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Johan RaederInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Frede FrihagenDepartment of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.
Anette Hylen RanhoffDepartment of Medicine, Diakonhjemmet Hospital, Oslo, Norway.
Farrukh Abbas ChaudhryInstitute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Knut EngedalInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Torgeir Bruun WyllerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bjørnar HasselDepartment of Complex Neurology and Neurohabilitation, Oslo University Hospital, N-0027, Oslo, Norway. bjornar.hassel@medisin.uio.no.
University of Oslo · NOOslo University Hospital · NOErasmus MC · NLSykehuset i Vestfold · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum.

methodsIn this prospective cohort study, 77 patients admitted with an acute hip fracture to Oslo University Hospital, Norway, were studied. The concentrations of amino acids in CSF and serum were determined by high performance liquid chromatography. The patients were assessed daily for delirium by the Confusion Assessment Method (pre-operatively and post-operative day 1-5 (all) or until discharge (delirious patients)). Pre-fracture dementia status was decided by an expert panel. Serum was collected pre-operatively and CSF immediately before spinal anesthesia.

resultsFifty-three (71 %) hip fracture patients developed delirium. In hip fracture patients without dementia (n = 39), those with delirium had significantly higher CSF levels of tryptophan (40 % higher), tyrosine (60 % higher), phenylalanine (59 % higher) and the monoamine metabolite 5-hydroxyindoleacetate (23 % higher) compared to those without delirium. The same amino acids were also higher in CSF in delirious patients with dementia (n = 38). The correlations between serum and CSF amino acid levels were poor.

conclusionHigher CSF levels of monoamine precursors in hip fracture patients with delirium suggest a higher monoaminergic activity in the central nervous system during delirium in this patient group.

Indexed as

DeliriumDementiaHip FracturesAgedAged, 80 and overChromatography, LiquidFemaleHumansIndolesMaleNorwayPhenylalaninePreoperative CareProspective StudiesPsychiatric Status Rating ScalesReproducibility of Resultsindole-3-lactic acidIndolesPhenylalanineTryptophanTyrosine

Identifiers

PMID27484129
PMCPMC4970288
OpenAlexW2499542551

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.