ArticleBlood transfusion = Trasfusione del sangue2017
Intravenous iron supplementation with intra-articular administration of tranexamic acid reduces the rate of allogeneic transfusions after simultaneous bilateral total knee arthroplasty.
Article in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The use of platelet-rich plasma in oral surgery: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- Second-knee transfusion burden persists under a high-dose intravenous iron protocol without tranexamic acid in one-week staged bilateral total knee arthroplasty: a paired cohort study.BMC musculoskeletal disorders · 2026Article
- Analysis of the incidence and risk factors of blood transfusion in total knee revision: a retrospective nationwide inpatient sample database study.BMC musculoskeletal disorders · 2024Article
- A Decline in Overutilization of Transfusion after Total Knee Arthroplasty Using Pharmacological Agents for Patient Blood Management in South Korea: An Analysis Based on the Korean National Health Insurance Claims Database from 2008 to 2019.Clinics in orthopedic surgery · 2023Article
- Should we use similar perioperative protocols in patients undergoing unilateral and bilateral one-stage total knee arthroplasty?World journal of orthopedics · 2022Article
- Perioperative management of elderly patients with osteoarthritis requiring total knee arthroplasty.Journal of perioperative practice · 2021Review
- The efficacy and safety of tranexamic acid for reducing blood loss following simultaneous bilateral total knee arthroplasty: a multicenter retrospective study.BMC musculoskeletal disorders · 2019Article
- Patient Blood Management: a revolutionary approach to transfusion medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- Perioperative intravenous tranexamic acid reduces blood transfusion in primary cementless total hip arthroplasty.Acta bio-medica : Atenei Parmensis · 2019Article
- Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia.Transfusion · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPeri-operative intravenous administration of iron supplementation seems a good option to reduce allogeneic blood transfusion in major orthopaedic surgery. However, its efficacy in simultaneous bilateral total knee arthroplasty has not been studied. MATERIALS AND
methodsFrom December 2014 to May 2015, a total of 72 consecutive patients underwent simultaneous bilateral total knee arthroplasty and received peri-operative intravenous iron supplementation (iron isomaltoside 1000: 600 mg pre-operatively and 400 mg 1 week post-operatively) and intra-articular tranexamic acid (2 g in 20 mL saline at the end of surgery), and were managed with a restrictive transfusion trigger (haemoglobin <7 g/dL). Post-operatively, we observed patients closely for symptoms of anaemia and checked their haemoglobin levels on days 1, 6 and 13 after surgery.
resultsThe mean baseline haemoglobin level was 13.1 g/dL. The levels remained above 7.0 g/dL on post-operative days 1, 6 and 13 (mean, 11.4 g/dL, 9.9 g/dL and 10.4 g/dL, respectively) in all but one patient who experienced melaena and required allogeneic blood transfusion. DISCUSSION: Intravenous iron supplementation combined with intra-articular administration of tranexamic acid seems to be an effective strategy for reducing the rate of allogeneic blood transfusion in patients undergoing simultaneous bilateral total knee arthroplasty managed with a restrictive transfusion trigger.
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