Evidence map›Paper›PMID 27483482›Full record

ReviewBlood transfusion = Trasfusione del sangue2017

Platelet gel: a new therapeutic tool with great potential.

Andrea Piccin, Angela M Di Pierro, Lucia Canzian, Marco Primerano, Daisy Corvetta, Giovanni Negri, Guido Mazzoleni, Günther Gastl, Michael Steurer, Ivo Gentilini and 2 more

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03890172 unknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of Platelets Rich Plasma as a Therapeutic Tool in Chronic Non Healing Diabetic Foot Ulcers

TypeobservationalSponsorAssiut UniversityRan2019 to 2021Enrolled60ConditionsDiabetic Foot UlcerArms20-100 ml venous blood will be drawn the from patient into sterilized centrifuge tube ,following centrifuge to separate PRP and at the bed side and tricked onto the ulcer twice weekly, standard treatment
NCT04145154 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of the Rich Plasma in Growth Factors on the Cicatrization of Diabetic Ulcers

TypeinterventionalSponsorUniversidad de GuanajuatoRan2018 to 2020Enrolled16ConditionsChronic Skin Ulcer, Diabetic Foot, Plasma Protein, Transport ProteinArmsApplication of platelet rich plasma in chronic wounds of diabetic origin
NCT06810726 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

EVALUATION OF THE SAFETY AND THE CLINICAL PERFORMANCE IN TREATMENT OF CHRONIC DIABETIC FOOT ULCER, WITH THE TROPOCELLS®, BASED AUTOLOGOUS PLATELET RICH FIBRIN (Tropocells(R) Autologous PRF Systems)

TypeinterventionalSponsorEstar Medical dba Medical Technologies, LTDRan2025 to 2026Enrolled30ConditionsDiabetic Foot Ulcer, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Neuroischemic Foot UlcerArmsPlatelet Rich Plasma
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  20. L-PRF in extra-oral wound care.Periodontology 2000 · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea PiccinHaematology Department, San Maurizio Regional Hospital, Bolzano, Austria.
Angela M Di PierroHaematology Department, San Maurizio Regional Hospital, Bolzano, Austria.
Lucia CanzianBlood Transfusion Service, San Maurizio Regional Hospital, Bolzano, Austria.
Marco PrimeranoRegenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.
Daisy CorvettaHaematology Department, San Maurizio Regional Hospital, Bolzano, Austria.
Giovanni NegriRegenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.
Guido MazzoleniRegenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.
Günther GastlDepartment of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
Michael SteurerDepartment of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
Ivo GentiliniBlood Transfusion Service, San Maurizio Regional Hospital, Bolzano, Austria.
Klaus EisendleRegenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.
Fabrizio FontanellaRegenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds, such as diabetic foot ulcers, represent a serious clinical problem for patients and clinicians. Management of these wounds has a strong economic impact worldwide. Complications resulting from injuries are a frequent cause of morbidity and mortality. Chronic wounds lead to infections, painful dressings and prolonged hospitalisation. This results in poor patient Quality of Life and in high healthcare costs. Platelet concentrates (PC) are defined as autologous or allogeneic platelet derivatives with a platelet concentration higher than baseline. PC are widely used in different areas of Regenerative Medicine in order to enhance wound healing processes; they include platelet-rich plasma (PRP), platelet gel (PG), platelet-rich fibrin (PRF), serum eye drops (E-S), and PRP eye drops (E-PRP). This review highlights the use of platelet-rich plasma (PRP) and platelet gel (PG) preparation for clinical use.

Indexed as

Blood PlateletsPlatelet-Rich FibrinDiabetic FootGelsHumansGels

Identifiers

PMID27483482
PMCPMC5490729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.