ArticlePloS one2016
Modelling Transcapillary Transport of Fluid and Proteins in Hemodialysis Patients.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Recent advances in interstitial fluid dynamics for diagnostic, targeted drug delivery and precision medicine applications.Drug delivery and translational research · 2026Review
- Mathematical models for phosphate kinetics in patients on maintenance hemodialysis.Scientific reports · 2025Article
- Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate.Scientific reports · 2023Article
- Transcapillary transport of water, small solutes and proteins during hemodialysis.Scientific reports · 2020Article
- A quantitativeInterface focus · 2019Article
- A Whole-Body Mathematical Model of Sepsis Progression and Treatment Designed in the BioGears Physiology Engine.Frontiers in physiology · 2019Article
- Hemodialysis-induced changes in hematocrit, hemoglobin and total protein: Implications for relative blood volume monitoring.PloS one · 2019Article
- In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability.PLoS computational biology · 2018Article
- Model of fluid and solute shifts during hemodialysis with active transport of sodium and potassium.PloS one · 2018Article
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5 authors.
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Abstract
backgroundThe kinetics of protein transport to and from the vascular compartment play a major role in the determination of fluid balance and plasma refilling during hemodialysis (HD) sessions. In this study we propose a whole-body mathematical model describing water and protein shifts across the capillary membrane during HD and compare its output to clinical data while evaluating the impact of choosing specific values for selected parameters.
methodsThe model follows a two-compartment structure (vascular and interstitial space) and is based on balance equations of protein mass and water volume in each compartment. The capillary membrane was described according to the three-pore theory. Two transport parameters, the fractional contribution of large pores (αLP) and the total hydraulic conductivity (LpS) of the capillary membrane, were estimated from patient data. Changes in the intensity and direction of individual fluid and solute flows through each part of the transport system were analyzed in relation to the choice of different values of small pores radius and fractional conductivity, lymphatic sensitivity to hydraulic pressure, and steady-state interstitial-to-plasma protein concentration ratio.
resultsThe estimated values of LpS and αLP were respectively 10.0 ± 8.4 mL/min/mmHg (mean ± standard deviation) and 0.062 ± 0.041. The model was able to predict with good accuracy the profiles of plasma volume and serum total protein concentration in most of the patients (average root-mean-square deviation < 2% of the measured value).
conclusionsThe applied model provides a mechanistic interpretation of fluid transport processes induced by ultrafiltration during HD, using a minimum of tuned parameters and assumptions. The simulated values of individual flows through each kind of pore and lymphatic absorption rate yielded by the model may suggest answers to unsolved questions on the relative impact of these not-measurable quantities on total vascular refilling and fluid balance.
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