ReviewMolecules (Basel, Switzerland)2016
Recent Advances in Metal-Free Quinoline Synthesis.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 156 citations in OpenAlex.
- Recent Advances in Quinoline Synthesis: Sustainable Catalytic Strategies and Emerging Methodologies.Molecules (Basel, Switzerland) · 2026Review
- Vistas in the domain of 3-acetyl-4-hydroxy-2-quinolinone derivatives (AHQ) and their applications.RSC advances · 2025Review
- Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Quinoline: A Novel Solution for Next-Generation Pesticides, Herbicides, and Fertilizers.Applied biochemistry and biotechnology · 2025Review
- 2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives.Molecules (Basel, Switzerland) · 2024Review
- The Catalysts-Based Synthetic Approaches to Quinolines: A Review.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024Review
- Microwave assisted one-pot access to pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivativesRSC advances · 2023Article
- Study and application of graphene oxide in the synthesis of 2,3-disubstituted quinolinesRSC advances · 2022Article
- 1Molecules (Basel, Switzerland) · 2022Review
- Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules.Chemical science · 2022Article
- Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive Review.Molecules (Basel, Switzerland) · 2021Review
- Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis.Molecules (Basel, Switzerland) · 2021Review
- An aza-Diels-Alder approach to chlorinated quinolines, benzoquinolines, and polybenzoquinolines.RSC advances · 2021Article
- Synthetic and medicinal perspective of quinolines as antiviral agents.European journal of medicinal chemistry · 2021Review
- Rapid and Efficient Microwave-Assisted Friedländer Quinoline Synthesis.ChemistryOpen · 2020Article
- Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review.RSC advances · 2020Review
- A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives.Molecules (Basel, Switzerland) · 2020Article
- Superacid-promoted synthesis of quinoline derivatives.Tetrahedron letters · 2020Article
- Article
- Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents.RSC advances · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quinoline ring system is one of the most ubiquitous heterocycles in the fields of medicinal and industrial chemistry, forming the scaffold for compounds of great significance. These include anti-inflammatory and antitumor agents, the antimalarial drugs quinine and chloroquine, and organic light-emitting diodes. Quinolines were first synthesized in 1879, and since then a multitude of synthetic routes have been developed. Many of these methods, such as the Skraup, Doebner-Von Miller, and Friedlander quinoline syntheses, are well-known but suffer from inefficiency, harsh reaction conditions, and toxic reagents. This review focuses on recent transition metal-free processes toward these important heterocycles, including both novel routes and modifications to established methods. For example, variations on the Skraup method include microwave irradiation, ionic liquid media, and novel annulation partners, all of which have shown increased reaction efficiency and improved yield of the heteroring-unsubstituted quinoline products. Similarly, modifications to other synthetic routes have been implemented, with the quinoline products displaying a wide variety of substitution patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.