ArticlePloS one2016
Shared Genetic Factors Involved in Celiac Disease, Type 2 Diabetes and Anorexia Nervosa Suggest Common Molecular Pathways for Chronic Diseases.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Is dieting a double-edged sword? Orthorexia in celiac disease.BMC psychiatry · 2026Article
- Avoidant/Restrictive Food Intake Disorder Is Common in Adult and Pediatric Patients with Celiac Disease and Non-Celiac Gluten Sensitivity.Nutrients · 2026Article
- Gastrointestinal morbidity in children whose mothers have anorexia nervosa: A longitudinal cohort study.Psychological medicine · 2025Article
- Association between single nucleotide polymorphisms inFrontiers in genetics · 2025Article
- Prevalence of eating disorders in patients with celiac disease: a comparative study with healthy individuals.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Gene expression analysis of intestinal IL-8, IL-17 A and IL-10 in patients with celiac and inflammatory bowel diseases.Molecular biology reports · 2022Article
- Disordered eating behaviors in adolescents with celiac disease.Eating and weight disorders : EWD · 2020Article
- Association Between Single Nucleotide Polymorphisms in PPARA and EPAS1 Genes and High-Altitude Appetite Loss in Chinese Young Men.Frontiers in physiology · 2019Article
- Investigating spousal concordance of diabetes through statistical analysis and data mining.PloS one · 2017Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesGenome-wide association studies (GWAS) have identified several genetic regions involved in immune-regulatory mechanisms to be associated with celiac disease. Previous GWAS also revealed an over-representation of genes involved in type 2 diabetes and anorexia nervosa associated with celiac disease, suggesting involvement of common metabolic pathways for development of these chronic diseases. The aim of this study was to extend these previous analyses to study the gene expression in the gut from children with active celiac disease. MATERIAL AND
methodsThirty six target genes involved in type 2 diabetes and four genes associated with anorexia nervosa were investigated for gene expression in small intestinal biopsies from 144 children with celiac disease at median (range) age of 7.4 years (1.6-17.8) and from 154 disease controls at a median (range) age 11.4.years (1.4-18.3).
resultsA total of eleven of genes were differently expressed in celiac patients compared with disease controls of which CD36, CD38, FOXP1, SELL, PPARA, PPARG, AGT previously associated with type 2 diabetes and AKAP6, NTNG1 with anorexia nervosa remained significant after correction for multiple testing.
conclusionShared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common underlying molecular pathways for these diseases.
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