Evidence map›Paper›PMID 27482750›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.

Jing Chao, Katya B Rubinow, Mario Kratz, John K Amory, Alvin M Matsumoto, Stephanie T Page

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men.American journal of physiology. Endocrinology and metabolism · 2017
    Article
  10. Observational
  11. Estrogens and Body Weight Regulation in Men.Advances in experimental medicine and biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jing ChaoCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
Katya B RubinowCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
Mario KratzCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
John K AmoryCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
Alvin M MatsumotoCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
Stephanie T PageCenter for Research in Reproduction and Contraception (J.C., K.B.R., S.T.P., J.K.A.) and Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition (K.B.R. and S.T.P.) and Division of Gerontology & Geriatric Medicine (A.M.M.), Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195; The Fred Hutchinson Cancer Research Center (M.K.); and the Geriatric Research, Education and Clinical Center (A.M.M.), VA Puget Sound Health Care System, Seattle, Washington 98108.
University of Washington · USGeriatric Research Education and Clinical Center · USVA Puget Sound Health Care System · US

Funding

Spermatogonial Stem Cell Self-Renewal and DifferentiationU54HD042454 · NICHD · UNIVERSITY OF WASHINGTON · PI PAGE, STEPHANIE T · 2002 to 2016
$26.9M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Men's Reproductive Health Research at the Univ of WashingtonK12HD053984 · NICHD · UNIVERSITY OF WASHINGTON · PI BREMNER, WILLIAM J · 2006 to 2016
$2.9M
Dose-response relationships between circulating and intraprostatic androgens in mR01AG037603 · NIA · UNIVERSITY OF WASHINGTON · PI PAGE, STEPHANIE T · 2010 to 2014
$1.6M
NHLBI NIH HHS T32 HL007028NIA NIH HHS R01 AG037603NICHD NIH HHS K12 HD053984NICHD NIH HHS U54 HD042454NIDDK NIH HHS T32 DK007247
6 · The paper itself

Abstract

contextT deprivation increases risk of insulin resistance in men, but whether this risk is independent of changes in body composition is unknown. Further, the metabolic roles of T and its metabolite estradiol have not been clearly defined in men.

objectiveThis study sought to establish the effects of selective sex steroid withdrawal on insulin sensitivity in healthy men. DESIGN, SETTING, AND

participantsThis was a double-blinded, placebo-controlled, randomized trial at an academic medical center of 56 healthy men, 19-55 years of age.

interventionsSubjects received the GnRH antagonist acyline plus one of the following: placebo gel (Castrate), 1.25 g testosterone gel (Low T/E), 5 g testosterone gel (Normal T/E), or 5 g testosterone gel with letrozole (Normal T/Low E) daily for 4 weeks. Body composition and glucose tolerance were assessed at baseline and end of treatment.

main outcome measureInsulin sensitivity was quantified by the Matsuda index.

resultsPredicted circulating sex steroid concentrations were achieved in all treatment groups. The time-by-group interaction for Matsuda index did not achieve significance in overall repeated measures ANOVA (baseline vs week 4; P = .16). A significant time-by-group interaction was observed for fat mass (P = .003), with changes in fat mass attributable predominantly to estrogen exposure in linear regression analysis (P = .016). A time-by-group interaction also was observed for lean mass (P = .03) and influenced by androgen exposure (P = .003).

conclusionsShort-term sex steroid withdrawal in healthy men causes adverse changes in body composition. These findings support the role of estradiol as a determinant of adiposity in men.

Indexed as

AdiposityInsulin ResistanceTestosteroneAdultAndrogensAromatase InhibitorsBlood GlucoseDouble-Blind MethodEstradiolGonadotropin-Releasing HormoneHormone AntagonistsHumansLetrozoleMaleMiddle AgedNitrilesAndrogensAromatase InhibitorsBlood GlucoseEstradiolGonadotropin-Releasing HormoneHormone AntagonistsLetrozoleNitrilesTestosteroneTriazoles

Identifiers

PMID27482750
PMCPMC5052347
OpenAlexW2504837934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.