ArticleBritish journal of cancer2016
De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I-III breast cancer.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Statins and prognosis of female breast cancer: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Pooled it
- Statin use and breast cancer-specific mortality and recurrence: a systematic review and meta-analysis including the role of immortal time bias and tumour characteristics.British journal of cancer · 2025Pooled it
- Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Impact of statin use on cancer-specific mortality and recurrence: A meta-analysis of 60 observational studies.Medicine · 2020Pooled it
- Association of statin use on survival outcomes of patients with early-stage HER2-positive breast cancer in the APHINITY trial.Breast cancer research and treatment · 2025Trial
- The impact of statins on prognostic outcomes in patients with non-metastatic solid cancers: a systematic review and meta-analysis.Discover oncology · 2026Review
- Statin use is associated with a lower risk of all-cause death in patients with breast cancer treated with anthracycline containing regimens: a global federated health database analysis.Clinical and experimental medicine · 2024Article
- Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort study.Breast cancer research and treatment · 2023Article
- Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study.Breast cancer research and treatment · 2021Article
- Association of antidiabetic medication and statins with survival from ductal and lobular breast carcinoma in women with type 2 diabetes.Scientific reports · 2021Article
- Statin use, HMGCR expression, and breast cancer survival - The Malmö Diet and Cancer Study.Scientific reports · 2020Article
- Statin use and breast cancer survival - a Swedish nationwide study.BMC cancer · 2019Article
- Statins enhance efficacy of venetoclax in blood cancers.Science translational medicine · 2018Article
- Statin Use and Breast Cancer Prognosis in Black and White Women.Hormones & cancer · 2018Article
- Effect of Statins on Survival Following Stroke in Patients With Cancer.Frontiers in neurology · 2018Article
- Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates.JCO clinical cancer informatics · 2017Article
- Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer.British journal of cancer · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior evidence suggests a role for statins in the management of cancer. However, the benefit of statin use in the adjuvant setting remains uncertain. This study investigates associations between statin use initiated after a breast cancer diagnosis and mortality.
methodsWomen with stage I-III breast cancer were identified from the National Cancer Registry of Ireland (N=4243). Post-diagnostic statin initiators were identified from pharmacy claims data (N=837). Multivariate models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between de novo statin use and mortality.
resultsThe median duration of statin use was 6.7 years. No association was found between post-diagnostic statin use and breast cancer-specific (HR 0.88, 95% CI 0.66, 1.17) or all-cause mortality (HR 1.00, 95% CI 0.82, 1.21).
conclusionsThe results from our study suggest that initiating statin use after a diagnosis of stage I-III breast cancer is not associated with a reduction in breast cancer-specific mortality.
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