ArticleInternational journal of environmental research and public health2016
Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation.
Article in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- An updated systematic review on the maternal exposure to environmental pesticides and involved mechanisms of autism spectrum disorder (ASD) progression risk in children.Reviews on environmental health · 2023Pooled it
- Association Between Biological Lead Concentrations and Autism Spectrum Disorder (ASD) in Children: a Systematic Review and Meta-Analysis.Biological trace element research · 2023Pooled it
- Pet Flea and Tick Control Exposure During Pregnancy and Early Life Associated with Decreased Cognitive and Adaptive Behaviors in Children with Developmental Delay and Autism Spectrum Disorder.International journal of environmental research and public health · 2025Article
- Professionally and non-professionally applied household insecticides during pregnancy and early life and their associations with autism spectrum disorder and developmental delay in the CHARGE case-control study.Environmental research · 2025Article
- Article
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- Review
- Article
- A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.Critical reviews in toxicology · 2022Review
- Household pesticide exposures and infant gross motor development in the MADRES cohort.Paediatric and perinatal epidemiology · 2022Article
- An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley.International journal of hygiene and environmental health · 2020Article
- Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder.Journal of translational medicine · 2019Article
- Pyrethroid pesticide metabolite, 3-PBA, in soils: method development and application to real agricultural soils.Environmental science and pollution research international · 2019Article
- Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.Journal of autism and developmental disorders · 2018Article
- Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning.Neurotoxicology · 2017Article
- A Review of the Field on Children's Exposure to Environmental Contaminants: A Risk Assessment Approach.International journal of environmental research and public health · 2017Review
- Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Article
- Children's Exposure to Environmental Contaminants: An Editorial Reflection of Articles in the IJERPH Special Issue Entitled, "Children's Exposure to Environmental Contaminants".International journal of environmental research and public health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well as the studies aimed at understanding the risk factors associated with the development of ASD. Since the etiology of ASD is partly genetic and partly environmental, factors (i.e., heavy metals, pesticides) as well as lifestyle seem to have a key role in the development of the disease. ASD and Control (CTR) children, aged 5-12 years, were compared. Gas chromatography coupled with trap mass detector was used to measure the level of 3-PBA, the main pyrethroid metabolite in urine in a group of ASD patients, while optical emission spectrometry analysis was employed to estimate the level of metals and microelements in hair in a different group of ASD children. The presence of 3-PBA in urine seems to be independent of age in ASD children, while a positive correlation between 3-PBA and age was observed in the control group of the same age range. Urine concentration of 3-BPA in ASD children had higher values than in the control group, which were marginally significant (p = 0.054). Mg results were significantly decreased in ASD with respect to controls, while V, S, Zn, and Ca/Mg were marginally increased, without reaching statistical significance. Results of Principal Component (PC) analysis of metals and microelements in hair were not associated with either age or health status. In conclusion, 3-PBA in urine and Mg in hair were changed in ASD children relative to control ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.