Evidence map›Paper›PMID 27482546›Full record

ArticleOpen life sciences2015

Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects.

Mee Rie Sheen, Sandra L Warner, Jennifer L Fields, Jose R Conejo-Garcia, Steven Fiering

Open access · goldAbstract read
In one paragraph

Article in Open life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mee Rie SheenDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States.
Sandra L WarnerDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States; Norris Cotton Cancer Center, Lebanon, NH 03756, United States.
Jennifer L FieldsDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States; Norris Cotton Cancer Center, Lebanon, NH 03756, United States.
Jose R Conejo-Garciaumor Microenvironment and Metastasis Program, the Wistar Institute, Philadelphia, PA 19104, United States.
Steven FieringDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States.
Dartmouth College · USCotton (United States) · USThe Wistar Institute · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Toxicology, Pathology and Biodistribution Core (TPB Core)U54CA151662 · NCI · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2010 to 2014
$11.6M
Vascular Leukocytes Influence the Tumor MicroenvironmentR01CA124515 · NCI · WISTAR INSTITUTE · PI Jose R Conejo-Garcia · 2007 to 2026
$7.1M
Center for Molecular, Cellular, and Translational ImmunologyP30GM103415 · NIGMS · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2012 to 2015
$4.7M
Initiation and Evolution of the Ovarian Cancer MicroenvironmentR01CA157664 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2011 to 2020
$3.8M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA124515NCI NIH HHS R01 CA157664NCI NIH HHS U54 CA151662NIGMS NIH HHS P30 GM103415
6 · The paper itself

Abstract

The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many important cellular functions. The functional impact of deregulating the

Indexed as

angiogenesisCre recombinaseembryonic developmenthemorrhagelethalitymorphological malformationmyristoylatedp110αPIK3CAvasculogenesis

Identifiers

PMID27482546
PMCPMC4966669
OpenAlexW2276387184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.