ArticleGerms2016
Low bone mineral density and associated risk factors in HIV-infected patients.
Article in Germs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Premature Skeletal Aging and Immunological Recovery in Romanian PLWH: A Cross-Sectional Analysis of Gender-Specific and Metabolic Risk Factors.International journal of molecular sciences · 2026Article
- Management and Outcomes of an Open Distal Femur Fracture in an HIV-Positive Patient: A Case Report From Madina Hospital, Somalia.International medical case reports journal · 2026Article
- Evaluation of Bone Mineral Density and Related Factors in Romanian HIV-Positive Patients Undergoing Antiretroviral Therapy.Microorganisms · 2025Article
- Bone Metabolism in Men who Live with HIV Aged 50 years and Over: Impact of Infection Duration.Current HIV research · 2024Article
- The evaluation of risk factors related to reduced bone mineral density in young people living with HIV.African health sciences · 2022Article
- Low bone mass and vitamin D in Brazilian people living with HIV under antiretroviral therapy.Archives of osteoporosis · 2022Article
- Effects of maximal strength training on bone mineral density in people living with HIV and receiving anti-retroviral therapy: a pilot study.BMC sports science, medicine & rehabilitation · 2020Article
- Article
- Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Quantitative ultrasonometry: An alternative and easy method to evaluate bone quality in people living with human immunodeficiency virus.Journal of musculoskeletal & neuronal interactions · 2019Observational
- Management of Reduced Bone Mineral Density in HIV: Pharmacological Challenges and the Role of Exercise.Frontiers in physiology · 2018Review
- Low bone mineral density among HIV-infected patients in Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Article
- HIV Infection and Bone Abnormalities.The open orthopaedics journal · 2017Article
- HYPOVITAMINOSIS D IN HIV-INFECTED PATIENTS.Acta endocrinologica (Bucharest, Romania : 2005)Article
- BONE QUALITY IN A YOUNG COHORT OF HIV-POSITIVE PATIENTS.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging of persons with human immunodeficiency virus (HIV) resulted in high rates of osteopenia and osteoporosis. Multiple cohort studies have reported an increased prevalence of bone demineralization among HIV-infected individuals. The aim of this study was to evaluate bone mineral density (BMD) and risk factors for osteopenia/osteoporosis among HIV-positive patients attending the National Institute for Infectious Diseases "Prof.Dr. Matei Balș", Bucharest, Romania.
methodsWe performed a cross-sectional study that enrolled 60 patients with HIV. The association between BMD and lifestyle habits (smoking), body mass index (BMI), nadir cluster of differentiation 4 (CD4) cell count, current CD4 cell count, HIV viral load and history of combination antiretroviral therapy (cART) were investigated. The BMD was measured at the lumbar spine, hips and total body using dual-energy X-ray absorptiometry (DEXA).
resultsIn the present study, DEXA evaluation showed an overall prevalence of osteoporosis of 16.66% (ten patients) and a prevalence of osteopenia of 48.33% (29 patients). In men, low BMI and cigarette smoking showed significant association with the diagnosis of lumbar spine demineralization (p=0.034 and p=0.041, respectively). Duration of exposure to cART classes in relation to BMD was also evaluated. The use of non-nucleoside reverse-transcriptase inhibitors (NNRTIs) was associated with low lumbar spine BMD in all patients (p=0.015). Reduced BMD was significantly associated with protease inhibitors (PIs)-containing treatment (p=0.043) in women.
conclusionAt lumbar spine DEXA, male gender was statistically associated with reduced BMD. At the left hip Ward's area, decreased BMD T scores were significantly associated with aging. The reduced BMD was higher in patients receiving PI- or NNRTI-containing regimens.
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