Evidence map›Paper›PMID 27482454›Full record

ArticleJournal of virus eradication2016

HIV pre-exposure prophylaxis for women.

Anandi N Sheth, Charlotte P Rolle, Monica Gandhi

Open access · goldAbstract read
In one paragraph

Article in Journal of virus eradication, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

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  15. Unveiling Risk: Marital Deception and HIV Susceptibility Among Married Women in Indonesia.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
    Article
  16. Acceptability of the live biotherapeutic LACTIN-V (Frontiers in reproductive health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anandi N ShethDepartment of Medicine, Division of Infectious Diseases , Emory University School of Medicine and Grady Health System , Atlanta , GA , USA.
Charlotte P RolleDepartment of Medicine, Division of Infectious Diseases , Emory University School of Medicine and Grady Health System , Atlanta , GA , USA.
Monica GandhiDepartment of Medicine, Division of HIV, Infectious Diseases, and Global Medicine , University of California San Francisco (UCSF) , San Francisco , CA , USA.
Emory University · USGrady Health System · USUniversity of California, San Francisco · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
Characterization and modulation of mucosal immunity for HIV prevention in womenK23AI114407 · NIAID · EMORY UNIVERSITY · PI SHETH, ANANDI NAYAN · 2014 to 2018
$898k
NIAID NIH HHS K23 AI114407NIAID NIH HHS P30 AI027763NIAID NIH HHS R37 AI098472NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

Women and girls comprise nearly half of HIV-infected individuals globally and 20% of new infections in the United States, indicating an urgent need to optimise HIV prevention options in this population. HIV pre-exposure prophylaxis (PrEP) - where antiretrovirals are administered to HIV-non-infected individuals at risk of HIV acquisition - is a promising, female-controlled HIV prevention strategy but has so far been underutilised in women. Clinical trial data demonstrate efficacy of daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for reduction of HIV acquisition among women when used consistently. Limited HIV risk perception and suboptimal PrEP awareness among women and healthcare personnel are among the challenges with PrEP delivery for women. Future research into the development of new drugs and delivery systems, and integrating PrEP delivery with reproductive healthcare services, provide opportunities to optimise this prevention strategy for women.

Indexed as

HIV preventionPre-exposure prophylaxiswomen's health

Identifiers

PMID27482454
PMCPMC4967966
OpenAlexW2503316431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.