Evidence map›Paper›PMID 27482393›Full record

ReviewJournal of virus eradication2015

Hepatitis E virus in developed countries: one of the most successful zoonotic viral diseases in human history?

Harry R Dalton, M Saunders, Kathy L Woolson

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in Journal of virus eradication, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The Common Mosquito (Frontiers in veterinary science · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. The Enigma of Hepatitis E Virus.Gastroenterology & hepatology · 2017
    Article
  12. Review
  13. Article
  14. Hepatitis E: an underestimated emerging threat.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Harry R DaltonRoyal Cornwall Hospital Trust, and; European Centre of Environment and Human Health, University of Exeter Medical School, Truro, UK.
M SaundersHepatology Unit , Derriford Hospital , Plymouth , UK.
Kathy L WoolsonHepatology Unit , Derriford Hospital , Plymouth , UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Until recently, hepatitis E was thought to be largely confined to hyperendemic areas in Asia, Africa and Mexico. Over the last 10 years it has become clear that this is not the case, as it is surprisingly common in developed countries. In these settings, it is caused by HEV genotypes 3 and 4, and is a porcine zoonosis. It causes a range of human illness including acute and chronic hepatitis, and a spectrum of neurological injury. HEV RNA has been found in donated blood from an increasing number of countries, and in some locations with a very high incidence. The clinical phenotype and burden of disease in humans is still emerging. In contrast to previous 'received wisdom', zoonotically transmitted HEV may be one of the most successful zoonotic viral infections in human history. How did we, as a scientific community, get this so badly wrong? This review considers this question from a largely clinical perspective, explores the places HEV has been 'hiding' and the emerging clinical phenotype in humans.

Indexed as

blood productshepatitishepatitis E virus (HEV)neurological injuryzoonosis

Identifiers

PMID27482393
PMCPMC4946667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.