ReviewMultidisciplinary respiratory medicine2016
Perimenstrual asthma: from pathophysiology to treatment strategies.
Review in Multidisciplinary respiratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- A Short-Term High-Sugar Diet Induces Glucose Intolerance, Visceral Adipose Tissue Inflammation, and Exacerbates Experimental Allergic Asthma.Nutrients · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Global, regional, and national burden of asthma from 1990 to 2021: analysis of data from global disease burden in 2021.BMC pulmonary medicine · 2025Article
- Gender and Allergy: Mechanisms, Clinical Phenotypes, and Therapeutic Response-A Position Paper from the Società Italiana di Allergologia, Asma ed Immunologia Clinica (SIAAIC).International journal of molecular sciences · 2025Review
- Decreases in Hormone Levels Modulate Neurovascular Coupling but Not Reduced Insular Functional Connectivity in Menstrual-Related Migraine.Human brain mapping · 2025Article
- Sex-Based Differences in Asthma: Pathophysiology, Hormonal Influence, and Genetic Mechanisms.International journal of molecular sciences · 2025Review
- Sex differences in airway disease: estrogen and airway surface liquid dynamics.Biology of sex differences · 2024Review
- Phytoestrogen-Based Hormonal Replacement Therapy Could Benefit Women Suffering Late-Onset Asthma.International journal of molecular sciences · 2023Review
- Asthma Phenotypes in the Era of Personalized Medicine.Journal of clinical medicine · 2023Review
- Effect of Obesity on Lung Function in the Pediatric and Adult Populations with Asthma: A Review.Journal of clinical medicine · 2023Review
- The "Asthma-Polycystic Ovary Overlap Syndrome" and the Therapeutic Role of Myo-Inositol.International journal of molecular sciences · 2023Review
- Association Between Asthma and Reduced Androgen Receptor Expression in Airways.Journal of the Endocrine Society · 2022Article
- Article
- Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology.Children (Basel, Switzerland) · 2022Review
- Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics.Cellular immunology · 2021Article
- Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma.Oxidative medicine and cellular longevity · 2021Review
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- 17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Sex Differences in Paediatric and Adult Asthma.European Medical Journal (Chelmsford, England) · 2019Article
- Can early intervention in pediatric asthma improve long-term outcomes? A question that needs an answer.Pediatric pulmonology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of asthma is about 9,7 % in women and 5,5 % in men. Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is distinguished from traditional allergic asthma by aspirin sensitivity, less atopy, and lower lung capacity. PMA incidence is reported to vary between 19 and 40 % of asthmatic women. The presence of PMA has been related to increases in asthma-related emergency department visits, hospitalizations and emergency treatment including intubations. It is hypothesized that hormonal status may influence asthma in women, focusing on the role of sex hormones, and specifically on the impact of estrogens' fluctuations at ovulation and before periods. This paper will focus on the pathophysiology of hormone triggered cycle related inflammatory/allergic events and their relation with asthma. We reviewed the scientific literature on Pubmed database for studies on PMA. Key word were PMA, mastcells, estrogens, inflammation, oral contraception, hormonal replacement therapy (HRT), and hormone free interval (HFI). Special attention will be devoted to the possibility of reducing the perimenstrual worsening of asthma and associated symptoms by reducing estrogens fluctuations, with appropriate hormonal contraception and reduced HFI. This novel therapeutical approach will be finally discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.