Evidence map›Paper›PMID 27482343›Full record

ArticleIranian journal of basic medical sciences2016

Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury.

Hui Young Lee, Hyun-Jin Tae, Geum-Sil Cho, In Hye Kim, Jeong Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Bai Hui Chen, Bich-Na Shin, Moo-Ho Won and 4 more

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PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hui Young LeeDepartment of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Hyun-Jin TaeDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea.
Geum-Sil ChoPharmacology & Toxicology Department, Shinpoong Pharmaceutical Co., Ltd., Ansan 425-100, South Korea.
In Hye KimDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Jeong Hwi ChoDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Joon Ha ParkDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Ji Hyeon AhnDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea.
Bai Hui ChenDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Bich-Na ShinDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Chan Woo ParkDepartment of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Jun Hwi ChoDepartment of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Jeong Yeol SeoDepartment of Emergency Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Jae-Chul LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea.
Kangwon National University · KRHallym University · KRShin Poong Pharm (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. MATERIALS AND

methodsIPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia.

resultsA lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days post-ischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia.

conclusionOur results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPC-mediated neuroprotection after a lethal ischemic insult.

Indexed as

Cells in stratum pyramidalec-mybDelayed neuronal deathIschemia-reperfusionIschemic preconditioningProtection

Identifiers

PMID27482343
PMCPMC4951601
OpenAlexW2468589615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.