Evidence map›Paper›PMID 27482295›Full record

ArticleGenes & nutrition2016

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study.

Lena Leder, Marjukka Kolehmainen, Ingunn Narverud, Ingrid Dahlman, Mari C W Myhrstad, Vanessa D de Mello, Jussi Paananen, Carsten Carlberg, Ursula Schwab, Karl-Heinz Herzig and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
  7. Thrombospondin 1 in Metabolic Diseases.Frontiers in endocrinology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 13 institutions in 6 countries.

Lena LederDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo Norway.
Marjukka KolehmainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Ingunn NarverudDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo Norway.
Ingrid DahlmanDepartment of Medicine (H7), Karolinska Institute, Stockholm, Sweden.
Mari C W MyhrstadDepartment of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.
Vanessa D de MelloInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jussi PaananenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Carsten CarlbergInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Ursula SchwabInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
Karl-Heinz HerzigInstitute of Biomedicine and Biocenter of Oulu, Medical Research Centre Oulu, Oulu, Finland ; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Lieselotte CloetensBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden.
Matilda Ulmius StormBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden.
Janne HukkanenBiocenter Oulu, University of Oulu, Oulu, Finland ; Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Markku J SavolainenBiocenter Oulu, University of Oulu, Oulu, Finland ; Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Fredrik RosqvistDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Kjeld HermansenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Lars O DragstedDepartment of Nutrition, Exercise and Sport, University of Copenhagen, Copenhagen, Denmark.
Ingibjörg GunnarsdottirUnit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
Inga ThorsdottirUnit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Björn ÅkessonBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden ; Department of Clinical Nutrition, Skåne University Hospital, Lund, Sweden.
Magne ThoresenDepartment of Biostatistics, University of Oslo, Oslo, Norway.
Peter ArnerDepartment of Medicine (H7), Karolinska Institute, Stockholm, Sweden.
Kaisa S PoutanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Matti UusitupaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Research Unit, Kuopio University Hospital, Kuopio, Finland.
Kirsten B HolvenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo Norway ; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Stine M UlvenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo Norway ; Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.
University of Eastern Finland · FILund University · SEUniversity of Oslo · NOKarolinska Institutet · SENational University Hospital of Iceland · ISOsloMet – Oslo Metropolitan University · NOOulu University Hospital · FIUppsala University · SEAarhus University Hospital · DKKuopio University Hospital · FIOslo University Hospital · NOPoznan University of Medical Sciences · PLUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in individuals with MetS.

methodsA Nordic multicenter randomized dietary study included subjects (n = 213) with MetS, randomized to a ND group or a control diet (CD) group applying an isocaloric study protocol. In this sub-study, we included subjects (n = 89) from three Nordic centers: Kuopio (n = 26), Lund (n = 30), and Oulu (n = 33) with a maximum weight change of ±4 kg, high-sensitivity C-reactive protein concentration ≤10 mg L(-1), and baseline body mass index <39 kg m(-2). PBMCs were isolated, and the mRNA gene expression analysis was measured by quantitative real-time polymerase chain reaction (qPCR). We analyzed the mRNA expression changes of 44 genes before and after a 2hOGTT at the beginning and the end of the intervention.

resultsThe healthy ND significantly down-regulated the expression of toll-like receptor 4 (TLR4), interleukin 18 (IL18), and thrombospondin receptor (CD36) mRNA transcripts and significantly up-regulated the expression of peroxisome proliferator-activated receptor delta (PPARD) mRNA transcript after the 2hOGTT compared to the CD.

conclusionsA healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings.

Indexed as

Metabolic syndromemRNA gene expressionNordic dietOGTTPBMCs

Identifiers

PMID27482295
PMCPMC4959556
OpenAlexW2299582691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.