Analysis of trace amounts of adulterants found in powders/supplements utilizing Raman spectroscopy coupled to direct analyte-probed nanoextraction-nanospray ionization-mass spectrometry.

Chinyere N Nnaji, Phillip M Mach, Jason S Acheampong, Travis M Falconer, Guido F Verbeck

Open access · greenAbstract read

In one paragraph

Article in Analytical methods : advancing methods and applications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.7field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

Interpol review of controlled substances 2016-2019.Forensic science international. Synergy · 2020
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chinyere N NnajiDepartment of Chemistry, University of North Texas, Denton, Texas, 76203, USA.

Phillip M MachDepartment of Chemistry, University of North Texas, Denton, Texas, 76203, USA.

Jason S AcheampongDepartment of Chemistry, University of North Texas, Denton, Texas, 76203, USA.

Travis M FalconerU.S. Food and Drug Administration, Forensic Chemistry Center, Cincinnati, Ohio, 45237, USA.

Guido F VerbeckDepartment of Chemistry, University of North Texas, Denton, Texas, 76203, USA.

University of North Texas · USFood and Drug Administration · TH

Funding

Intramural FDA HHS FD999999

6 · The paper itself

Abstract

In the United States, all food products have to be regulated to inform the consumers of the ingredients contained within. Some ingredients are not included on the label and yet are still found in the products. Presented is a Raman imaging technique for rapid, nondestructive, and spatially relevant localization of adulterants in powders. Raman spectroscopy followed by direct analyte-probed nanoextraction coupled to nanospray ionization-mass spectrometry allows rapid determination of the presence of each adulterant, leading to positive identifications such as melamine. The location and identification of these trace particles can then be extracted using a nanomanipulator. The nanomanipulation technique uses a solvent filled capillary tip which can be positioned on the particle of interest. Direct mass spectrometric analysis

Identifiers

PMID27482293

DOI10.1039/C6AY00828C

PMCPMC4960828

OpenAlexW2408275715

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.