Evidence map›Paper›PMID 27482264›Full record

ArticleKorean circulation journal2016

Non-Responders to Intravenous Immunoglobulin and Coronary Artery Dilatation in Kawasaki Disease: Predictive Parameters in Korean Children.

Bo Young Kim, Dongwan Kim, Yong Hyun Kim, Eell Ryoo, Yong Han Sun, In-Sang Jeon, Mi-Jin Jung, Hye Kyung Cho, Hann Tchah, Deok Young Choi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean circulation journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  20. Adjunctive therapies in Kawasaki disease.International journal of rheumatic diseases · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Bo Young KimDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Dongwan KimDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Yong Hyun KimDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Eell RyooDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Yong Han SunDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
In-Sang JeonDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Mi-Jin JungDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Hye Kyung ChoDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Hann TchahDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Deok Young ChoiDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Na Yeon KimDepartment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Gachon University Gil Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn Kawasaki disease (KD), high dose intravenous immunoglobulin (IVIG) significantly lowers the coronary complications. However, some patients either do not respond to initial therapy or develop coronary complications. We aimed to identify the predictive factors for unresponsiveness to initial IVIG therapy and coronary artery dilatation (CAD; defined by Z-score≥2.5) in the acute phase and convalescent phase. SUBJECTS AND

methodsA retrospective review was conducted of 703 patients with KD, admitted to Gachon University Gil Medical Center between January 2005 and June 2013. The patients were divided into two groups-IVIG responders vs. non-responders-based on the IVIG treatments, and presence of fever after treatment. Further, these groups were divided into two subgroups based on their CAD.

resultsAmong the 703 patients with KD, the rate of non-responders to initial IVIG was 16.8%. Serum total bilirubin, platelet count, and neutrophil proportion were independent predictive parameters of unresponsiveness (p<0.05). CAD was found in 234 patients (33.3%) in the acute phase, and in 32 patients (4.6%) in the convalescent phase. Male gender, fever duration, serum C-reactive protein, and white blood cell count were related to CAD (p<0.05). CAD was detected more frequently in non-responders than in the responders (47.5% vs. 31.5%, p=0.001). Kobayashi, Egami, and Sano scoring systems applied to our study population reflected low sensitivities (28.0-33.9%).

conclusionSeveral independent parameters were related to unresponsiveness to the initial IVIG or CAD. These parameters might be helpful in establishing more focused and careful monitoring of high-risk KD patients in Korea.

Indexed as

ChildrenCoronary arteriesIntravenous immunoglobulinsKawasaki disease

Identifiers

PMID27482264
PMCPMC4965434
OpenAlexW2262507546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.