ArticleKorean circulation journal2016
Multimodality Intravascular Imaging Assessment of Plaque Erosion versus Plaque Rupture in Patients with Acute Coronary Syndrome.
Article in Korean circulation journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Reply to Letter to the Editor: "Unmet Need for Deep Diving into Intracoronary Imaging".Anatolian journal of cardiology · 2025Article
- Risk Factors Favoring Plaque Erosion.Current atherosclerosis reports · 2024Review
- The influence between plaque rupture and non-plaque rupture on clinical outcomes in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention: a prospective cohort study.Journal of thoracic disease · 2024Article
- New Insights into Pathophysiology and New Risk Factors for ACS.Journal of clinical medicine · 2023Review
- Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions.Nature reviews. Cardiology · 2021Review
- Atherothrombosis in Acute Coronary Syndromes-From Mechanistic Insights to Targeted Therapies.Cells · 2021Review
- Immune Mechanisms of Plaque Instability.Frontiers in cardiovascular medicine · 2021Review
- Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome.Scientific reports · 2020Article
- Rediscover a Missed Culprit Lesion with Optical Coherence Tomography in Acute Coronary Syndrome: a Simple Stationary Pullback Method.Korean circulation journal · 2020Article
- Morphological characteristics of optical coherence tomography defined plaque fissure in patients with acute coronary syndrome.Heart and vessels · 2019Article
- Plaque erosion: a new in vivo diagnosis and a potential major shift in the management of patients with acute coronary syndromes.European heart journal · 2018Review
- Nonculprit Plaque Characteristics in Patients With Acute Coronary Syndrome Caused by Plaque Erosion vs Plaque Rupture: A 3-Vessel Optical Coherence Tomography Study.JAMA cardiology · 2018Observational
- Optical coherence tomography guided successful fibrinolytic treatment without the need for percutaneous coronary intervention in a patient with acute ST-segment elevation myocardial infarction.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2018Article
- Can OCT change the therapeutic strategy in ACS due to plaque erosion?Indian heart journalReview
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWe assessed plaque erosion of culprit lesions in patients with acute coronary syndrome in real world practice. SUBJECTS AND
methodsCulprit lesion plaque rupture or plaque erosion was diagnosed with optical coherence tomography (OCT). Intravascular ultrasound (IVUS) was used to determine arterial remodeling. Positive remodeling was defined as a remodeling index (lesion/reference EEM [external elastic membrane area) >1.05.
resultsA total of 90 patients who had plaque rupture showing fibrous-cap discontinuity and ruptured cavity were enrolled. 36 patients showed definite OCT-plaque erosion, while 7 patients had probable OCT-plaque erosion. Overall, 26% (11/43) of definite/probable plaque erosion had non-ST elevation myocardial infarction (NSTEMI) while 35% (15/43) had ST elevation myocardial infarction (STEMI). Conversely, 14.5% (13/90) of plaque rupture had NSTEMI while 71% (64/90) had STEMI (p<0.0001). Among plaque erosion, white thrombus was seen in 55.8% (24/43) of patients and red thrombus in 27.9% (12/43) of patients. Compared to plaque erosion, plaque rupture more often showed positive remodeling (p=0.003) with a larger necrotic core area examined by virtual histology (VH)-IVUS, while negative remodeling was prominent in plaque erosion. Overall, 65% 28/43 of plaque erosions were located in the proximal 30 mm of a culprit vessel-similar to plaque ruptures (72%, 65/90, p=0.29).
conclusionAlthough most of plaque erosions show nearly normal coronary angiogram, modest plaque burden with negative remodeling and an uncommon fibroatheroma might be the nature of plaque erosion. Multimodality intravascular imaging with OCT and VH-IVUS showed fundamentally different pathoanatomic substrates underlying plaque rupture and erosion.
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