Evidence map›Paper›PMID 27482256›Full record

ArticleKorean circulation journal2016

Effect of n-3 Polyunsaturated Fatty Acids on Regression of Coronary Atherosclerosis in Statin Treated Patients Undergoing Percutaneous Coronary Intervention.

Jinhee Ahn, Seo Kwang Park, Tae Sik Park, Jin Hee Kim, Eunyoung Yun, Sang-Pil Kim, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Kwang Soo Cha and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean circulation journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 9 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 9 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jinhee AhnDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Seo Kwang ParkDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Tae Sik ParkDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Jin Hee KimDepartment of Internal Medicine, Busan Medical Center, Busan, Korea.
Eunyoung YunDepartment of Biostatistics, Pusan National University Hospital, Busan, Korea.
Sang-Pil KimDepartment of Cardiovascular Surgery, Pusan National University Hospital, Busan, Korea.
Hye Won LeeDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Jun-Hyok OhDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Jung Hyun ChoiDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Kwang Soo ChaDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Taek Jong HongDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Sang Yeoup LeeFamily Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, Yangsan, Korea.
Han Cheol LeeDivision of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Pusan National University Hospital · KRBusan Medical Center · KRPusan National University Yangsan Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesStatins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (ω-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. However, data on the possible antiatherosclerotic benefits of adding ω-3 PUFA to statin therapy are limited. This study aimed to investigate the potential additive effects of ω-3 PUFA on regression of atherosclerosis in CAD patients receiving statin therapy and stent implantation. SUBJECTS AND

methodsSeventy-four CAD patients undergoing percutaneous coronary intervention (PCI) with stent implantation were enrolled, prescribed statins, and randomly assigned to two groups: n-3 group (ω-3 PUFA 3 g/day, n=38) or placebo group (placebo, n=36). All patients completed the study follow-up consisting of an intravascular ultrasound at baseline and at 12 months.

resultsThere was no difference in the baseline characteristics and distribution of other medications. No significant differences were observed in primary endpoints, including changes in atheroma volume index (-12.65% vs. -8.51%, p=0.768) and percent atheroma volume (-4.36% vs. -9.98%, p=0.526), and in secondary endpoints including a change in neointimal volume index (7.84 vs. 4.94 mm(3)/mm, p=0.087).

conclusionω-3 PUFA had no definite additional effect on the regression of coronary atherosclerosis when added to statin in CAD patients undergoing PCI.

Indexed as

AtherosclerosisCoronary artery diseasen-3 polyunsaturated fatty acidsStatin

Identifiers

PMID27482256
PMCPMC4965426
OpenAlexW2500853188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.