Evidence map›Paper›PMID 27482235›Full record

ReviewNeural regeneration research2016

Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies.

Guihong Li, Fengbo Yu, Ting Lei, Haijun Gao, Peiwen Li, Yuxue Sun, Haiyan Huang, Qingchun Mu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Guihong LiDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China; Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
Fengbo YuSchool of Pharmacy, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
Ting LeiDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Haijun GaoDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Peiwen LiDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Yuxue SunDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Haiyan HuangDepartment of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Qingchun MuDepartment of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.ORCID 0000-0003-1082-2692
First Hospital of Jilin University · CNJilin University · CNMudanjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction, angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action, and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke. We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.

Indexed as

angiogenesisanimal modelclinical applicationgenetic modificationischemia/reperfusion injurymechanisms of actionnerve regenerationneural regenerationreplacement therapyresearch progress

Identifiers

PMID27482235
PMCPMC4962565
OpenAlexW2465441676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.