ArticleNeural regeneration research2016
Establishment of a rat model of chronic thoracolumbar cord compression with a flat plastic screw.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging.Fluids and barriers of the CNS · 2023Article
- Animal models of compression spinal cord injury.Journal of neuroscience research · 2022Review
- Progressive spinal cord compression technique in experimental rabbit animal model for cervical spondylotic myelopathy.Annals of medicine and surgery (2012) · 2021Article
- Changes in neurological and pathological outcomes in a modified rat spinal cord injury model with closed canal.Neural regeneration research · 2020Article
- Experimental rat model for cervical compressive myelopathy.Neuroreport · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies of animal models of chronic mechanical compression of the spinal cord have mainly focused on cervical and thoracic lesions, but few studies have investigated thoracolumbar injury. The specific pathophysiological mechanism of chronic thoracolumbar cord injury has not yet been elucidated. The purpose of this study was to improve animal models of chronic thoracolumbar cord compression using the progressive screw. A custom-designed flat plastic screw was implanted in the spinal cord between thoracic vertebrae 12 and lumbar 1 of rats. The screw was tightened one complete turn (0.5 mm) every 7 days for 4 weeks to create different levels of chronic spinal cord compression. Following insertion of the screw, there was a significant decline in motor function of the hind limbs, and severe stenosis of micro-computed tomography parameters in the spinal cord. Cortical somatosensory evoked potential amplitudes were reduced remarkably, and latencies were prolonged at 30 minutes after surgery. The loss of motor neurons in the gray matter was marked. Demyelination and cavitation were observed in the white matter. An appropriate rat model of chronic thoracolumbar cord compression was successfully created using the progressive screw compression method, which simulated spinal cord compression injury.
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