ArticleActa informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH2016
Usefulness of Total PSA Value in Prostate Diseases Diagnosis.
Article in Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Correlating Histological Results and Total Serum Levels of the Prostate-Specific Antigen Among Patients in Southwestern Uganda.Prostate cancer · 2026Article
- Correlation of Prostate-Specific Antigen (PSA), Prostate Volume, and Histology in Ugandan Males.Cureus · 2025Article
- Development of a first-in-class antibody and a specific assay for α-1,6-fucosylated prostate-specific antigen.Scientific reports · 2024Article
- A single-center, multi-factor, retrospective study to improve the diagnostic accuracy of primary prostate cancer using [European journal of nuclear medicine and molecular imaging · 2024Article
- miRNA-21 as High Potential Prostate Cancer Biomarker in Prostate Cancer Patients in Indonesia.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
- Assessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions.Scientific reports · 2022Article
- miR-148a, miR-152 and miR-200b promote prostate cancer metastasis by targeting DNMT1 and PTEN expression.Oncology letters · 2021Article
- Proteolyzed Variant of IgG with Free C-Terminal Lysine as a Biomarker of Prostate Cancer.Biology · 2021Article
- Article
- Elevated PSA level as a warning of mesh rejection risk after combined laparoscopic totally extraperitoneal hernia repair and transurethral resection of prostate: Case report.International journal of surgery case reports · 2019Article
- A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure.Scientific reports · 2017Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnalysis of total value of prostate specific antigen (PSAT), with the unavoidable digital rectal examination (DRE) is the basis of prostate cancer detection.
aimThe aim of this study was to determine the specificity and sensitivity of the total value of PSAT in the diagnosis of prostate cancer. The aim was also to determine the significance of PSAT in diagnosis of benign prostate hyperplasia, precancerous conditions and inflammatory and atrophic changes of the prostate. MATERIAL AND
methodsData were collected from the "Register of PH biopsy" of Clinic of Urology, CCU Sarajevo.
resultsAnalysis of correlation between the diagnosis and the PSAT value shows statistically significant negative correlation (r =-0,186; p = 0.006) in the sense that the value of the PSAT is highest in cancer patients, and the lowest in patients with benign prostatic hyperplasia. PSAT increases with age (r = 0.152; p = 0.025). For prostate cancer optimal sensitivity and specificity for PSAT value occurs at cut off value of> 8.6 ng /mL. Values lower than 2 ng/mL and higher than 10 ng/mL are most specific, and PPV increases with increasing value of PSAT. PSAT at values of <2 ng/mL and > 10 ng/mL are at high levels of specificity, and value > 10 ng / mL is also of high sensitivity in the detection of prostate cancer, and in this moment these values represent the optimal mode for the subsequent treatment.
conclusionPSAT has a relative significance in the detection of prostate cancer, and should not be used as a guideline without DRE.
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