Trial reportProceedings of the National Academy of Sciences of the United States of America2016
Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies.Social cognitive and affective neuroscience · 2017Pooled it
- Oxytocin facilitates valence-dependent valuation of social evaluation of the self.Communications biology · 2020Trial
- Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence.Social cognitive and affective neuroscience · 2017Trial
- A Theoretical Framework for Studying the Phenomenon of Gaslighting.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026Review
- Self-allocation bias in performance-based cooperative decisions is driven by self-interest rather than distorted performance encoding.PLoS biology · 2026Article
- Article
- There is no belief update bias for neutral events: failure to replicate Burton et al. (2022).Journal of cognitive psychology (Hove, England) · 2023Article
- Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols.Pharmaceutics · 2022Review
- Oxytocin and the Punitive Hub-Dynamic Spread of Cooperation in Human Social Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?Aging and disease · 2021Review
- Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide.International journal of molecular sciences · 2021Review
- HJournal of clinical medicine · 2021Article
- Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research.Molecular psychiatry · 2021Review
- Article
- Article
- The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System.Antioxidants (Basel, Switzerland) · 2020Article
- Oxytocin modulates social value representations in the amygdala.Nature neuroscience · 2019Article
- Article
- Social value orientation modulates the processing of outcome evaluation involving others.Social cognitive and affective neuroscience · 2017Article
- Effects of Oxytocin and Vasopressin on Preferential Brain Responses to Negative Social Feedback.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans update their beliefs upon feedback and, accordingly, modify their behaviors to adapt to the complex, changing social environment. However, people tend to incorporate desirable (better than expected) feedback into their beliefs but to discount undesirable (worse than expected) feedback. Such optimistic updating has evolved as an advantageous mechanism for social adaptation. Here, we examine the role of oxytocin (OT)-an evolutionary ancient neuropeptide pivotal for social adaptation-in belief updating upon desirable and undesirable feedback in three studies (n = 320). Using a double-blind, placebo-controlled between-subjects design, we show that intranasally administered OT (IN-OT) augments optimistic belief updating by facilitating updates of desirable feedback but impairing updates of undesirable feedback. The IN-OT-induced impairment in belief updating upon undesirable feedback is more salient in individuals with high, rather than with low, depression or anxiety traits. IN-OT selectively enhances learning rate (the strength of association between estimation error and subsequent update) of desirable feedback. IN-OT also increases participants' confidence in their estimates after receiving desirable but not undesirable feedback, and the OT effect on confidence updating upon desirable feedback mediates the effect of IN-OT on optimistic belief updating. Our findings reveal distinct functional roles of OT in updating the first-order estimation and second-order confidence judgment in response to desirable and undesirable feedback, suggesting a molecular substrate for optimistic belief updating.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.