Evidence map›Paper›PMID 27481618›Full record

Observational studyBMJ open2016

Uptake of childhood influenza vaccine from 2012-2013 to 2014-2015 in the UK and the implications for high-risk children: a retrospective observational cohort study.

Sankarasubramanian Rajaram, Amy Steffey, Betina Blak, Matthew Hickman, Hannah Christensen, Herve Caspard

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sankarasubramanian RajaramGlobal Medical Affairs, AstraZeneca, Luton, UK.
Amy SteffeyMedical Affairs, MedImmune, Gaithersburg, Maryland, USA.
Betina BlakPayer Evidence Group, AstraZeneca, Luton, UK.
Matthew HickmanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Hannah ChristensenSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Herve CaspardMedical Affairs, MedImmune, Gaithersburg, Maryland, USA.

Funding

Medical Research Council MR/K023233/1
6 · The paper itself

Abstract

objectivesTo evaluate changes in influenza vaccination rates in healthy and at-risk children following the implementation of the UK's childhood influenza immunisation programme.

designObservational cohort study before and after initiation of the UK's childhood influenza immunisation programme over three influenza seasons (2012-2013, 2013-2014 and 2014-2015) using data from the Clinical Practice Research Datalink (CPRD).

settingMore than 500 primary care practices in the UK. POPULATION: All individuals aged 2-17 years on 1 September, with at least 12 months of medical history documented in CPRD were retained in the analysis.

interventionStarting in 2013-2014, all children aged 2 and 3 years were offered influenza vaccination through general practice, and primary school-aged children were offered influenza vaccination in selected counties in England (described as pilot regions). The vaccination programme was extended to all children aged 4 years in England in 2014-2015.

main outcome measureCumulative vaccination rate from 1 September to 28 February of the next calendar year as assessed by a time-to-event statistical model (vaccination uptake). Age group, sex, region and type of high-risk medical condition were assessed as predictors.

resultsVaccination uptake increased considerably from 2012-2013 to 2013-2014 in targeted children aged 2-3 years, both in children with a high-risk medical condition (from 40.7% to 61.1%) and those without (from 1.0% to 43.0%). Vaccination rates increased also, though less markedly, in older children. In 2014-2015, vaccination rates remained higher than 40% in healthy children aged 2-3 years, although they decreased slightly from 2013-2014 (from 43.0% to 41.8%). Vaccination rates in older healthy children continued to increase, driven primarily by an increase in children aged 4 years to 31.3% in 2014-2015.

conclusionsThe introduction of a universal childhood vaccination policy in the UK increased vaccination rates for targeted children, including those with high-risk conditions.

Indexed as

Health Services AccessibilityHealth StatusImmunization ProgramsInfluenza VaccinesChildChild, PreschoolEnglandFamily PracticeFemaleHumansInfluenza, HumanMalePatient Acceptance of Health CarePrimary Health CareRetrospective StudiesRisk FactorsInfluenza VaccinesHigh-riskInfluenzaPaediatricUptakeVaccination

Identifiers

PMID27481618
PMCPMC4985803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.