Evidence map›Paper›PMID 27481530›Full record

ArticleAIDS research and human retroviruses2017

Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana.

Sikhulile Moyo, Kenanao P Kotokwe, Terence Mohammed, Corretah Boleo, Lucy Mupfumi, Samuel Chishala, Lesedi Tsalaile, Hermann Bussmann, Simani Gaseitsiwe, Rosemary Musonda and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Sikhulile Moyo1 Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg, South Africa .
Kenanao P Kotokwe2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Terence Mohammed2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Corretah Boleo2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Lucy Mupfumi2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Samuel Chishala1 Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg, South Africa .
Lesedi Tsalaile1 Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg, South Africa .
Hermann Bussmann2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Simani Gaseitsiwe2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Rosemary Musonda2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Joseph Makhema2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Marianna Baum5 Florida International University , College of Health and Urban Affairs, Miami, Florida.
Richard Marlink2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Susan Engelbrecht1 Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg, South Africa .
Max Essex2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Vladimir Novitsky2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USStellenbosch University · ZAFlorida International University · US

Funding

HIV Disease, Drug Abuse, &Nutrient Therapy in BotswanaR01DA016551 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2003 to 2007
$3.8M
NIDA NIH HHS R01 DA016551
6 · The paper itself

Abstract

Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5-2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46-1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11-0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.

Indexed as

Antibody AffinityDiagnostic ErrorsAdultBotswanaFemaleHIV AntigensHIV InfectionsHumansImmunoassayIncidenceMaleMolecular Diagnostic TechniquesRNA, ViralHIV AntigensRNA, Viralcross-sectional incidencefalse recency rateHIV incidenceHIV recencylimiting antigen assay

Identifiers

PMID27481530
PMCPMC5239999
OpenAlexW2518698667

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.