ArticleJournal of fluorescence2016
Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies.
Article in Journal of fluorescence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 107 citations in OpenAlex.
- Enhancing Antimicrobial Efficacy: The Role of Metal Complexation in Chitosan-Based Antimicrobial Agents.Applied biochemistry and biotechnology · 2026Review
- Iron(II) and Copper(II) Ions Modulating Binding Interaction of Sugar-Based Silatrane With DNA: Analytical and Theoretical Validation.Chemistry & biodiversity · 2026Article
- Advancements in pharmaceutical research on traditional Chinese medicine-metal complexes.Journal of pharmaceutical analysis · 2026Review
- Interaction of flavonoids with DNA: implications in cancer treatment.Molecular biology reports · 2026Review
- 6-Aminoflavone Inhibits Planktonic Growth, Disrupts Biofilm Architecture, and Regulates Quorum Sensing inBiochemistry research international · 2026Article
- Redox properties of quercetin iron Ii complex with enhanced antioxidant and antiviral activities.Scientific reports · 2025Article
- Deciphering the mechanisms of antibacterial and antibiofilm potential of phenolic compounds against Serratia marcescens.Bioresources and bioprocessing · 2025Article
- Production of Prophylactic Nanoformulation for Dental Caries and Investigation of Its Effectiveness by In Vitro and In Silico Methods.Pharmaceutics · 2025Article
- Enhanced Bioactivity of Quercetin-Tetrahydroisoquinoline Derivatives: Effect on Lipophilicity, Enzymes Inhibition, Antioxidant Potential, and Cytotoxicity.International journal of molecular sciences · 2024Article
- Metal-Flavonoid Interactions-From Simple Complexes to Advanced Systems.Molecules (Basel, Switzerland) · 2024Review
- Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II).International journal of molecular sciences · 2023Article
- The parallel biosynthesis routes of hyperoside from naringenin inHorticulture research · 2023Article
- Nutritional Provision of Iron Complexes by the Major Allergen Alt a 1 to Human Immune Cells Decreases Its Presentation.International journal of molecular sciences · 2023Article
- Preparation of Nanoparticle-Loaded Extracellular Vesicles Using Direct Flow Filtration.Pharmaceutics · 2023Article
- Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications.Pharmaceutics · 2023Review
- Synthesis and Characterization of Quercetin-Iron Complex Nanoparticles for Overcoming Drug Resistance.Pharmaceutics · 2023Article
- Optimization of Flavonoid Extraction fromMolecules (Basel, Switzerland) · 2022Article
- Site-Selective Coordination Assembly of Dynamic Metal-Phenolic Networks.Angewandte Chemie (International ed. in English) · 2022Article
- Overview of Research on Vanadium-Quercetin Complexes with a Historical Outline.Antioxidants (Basel, Switzerland) · 2022Review
- Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quercetin-iron (II) complex was synthesized and characterized by elemental analysis, ultraviolet-visible spectrophotometry, fourier transform infrared spectroscopy, mass spectrometry, proton nuclear magnetic resonance spectroscopy, thermogravimetry and differential scanning calorimetry, scanning electron micrography and molar conductivity. The low molar conductivity value investigates the non-electrolyte nature of the complex. The elemental analysis and other physical and spectroscopic methods reveal the 1:2 stoichiometric ratio (metal:ligand) of the complex. Antioxidant study of the quercetin and its metal complex against 2, 2-di-phenyl-1-picryl hydrazyl radical showed that the complex has much more radical scavenging activity than free quercetin. The interaction of quercetin-iron (II) complex with DNA was determined using ultraviolet visible spectra, fluorescence spectra and agarose gel electrophoresis. The results showed that quercetin-iron (II) complex can intercalate moderately with DNA, quench a strong intercalator ethidium bromide and compete for the intercalative binding sites. The complex showed significant cleavage of pBR 322 DNA from supercoiled form to nicked circular form and these cleavage effects were dose-dependent. Moreover, the mechanism of DNA cleavage indicated that it was an oxidative cleavage pathway. These results revealed the potential nuclease activity of complex to cleave DNA. In addition, antibacterial activity of complex on E.coli and S. aureus was also investigated. The results showed that complex has higher antibacterial activity than ligand.
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Registered trials
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