ArticleNeurosurgical review2017
Brain tumors in eloquent areas: A European multicenter survey of intraoperative mapping techniques, intraoperative seizures occurrence, and antiepileptic drug prophylaxis.
Article in Neurosurgical review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Management of epilepsy in brain tumors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Guideline
- Comparative analysis of monotherapy versus duotherapy with antiseizure medications for intraoperative and early postoperative seizure control in glioma patients undergoing awake craniotomy.Journal of neuro-oncology · 2025Article
- Impact of weight classes on feasibility, safety, and efficacy of awake craniotomy for brain lesions within eloquent areas.Neurosurgical review · 2025Observational
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- Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
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- Detection of face motor activation in the precentral gyrus with functional thermography following inconclusive direct electrical stimulation mapping: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience.Cancers · 2024Article
- Guidelines for Awake Surgery.Neurologia medico-chirurgica · 2024Article
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- Resection of Low-Grade Gliomas in the Face Area of the Primary Motor Cortex and Neurological Outcome.Cancers · 2023Article
- Case Report: "Aggressive" perioperative antiseizure medication prophylaxis in patients with glioma-related epilepsy at high risk of early postoperative seizures following awake craniotomy.Frontiers in surgery · 2023Article
- Feasibility of intraoperative neuromonitoring and cortical/subcortical mapping in patients with cerebral lesions of highly functional localizations-pathway to case adapted monitoring and mapping procedures.Frontiers in oncology · 2023Article
- Variables associated with cortical motor mapping thresholds: A retrospective data review with a unique case of interlimb motor facilitation.Frontiers in neurology · 2023Article
- Risk factors and predictors of intraoperative seizures during awake craniotomy: A systematic review and meta-analysis.Surgical neurology international · 2023Review
- Perioperative levetiracetam for seizure prophylaxis in seizure-naive brain tumor patients with focus on neurocognitive functioning.BMC neurology · 2022Article
- Global comparison of awake and asleep mapping procedures in glioma surgery: An international multicenter survey.Neuro-oncology practice · 2022Article
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- The Relationship Between Stimulation Current and Functional Site Localization During Brain Mapping.Neurosurgery · 2021Article
Corrections and comments
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Authors and funding
22 authors at 16 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative mapping and monitoring techniques for eloquent area tumors are routinely used world wide. Very few data are available regarding mapping and monitoring methods and preferences, intraoperative seizures occurrence and perioperative antiepileptic drug management. A questionnaire was sent to 20 European centers with experience in intraoperative mapping or neurophysiological monitoring for the treatment of eloquent area tumors. Fifteen centers returned the completed questionnaires. Data was available on 2098 patients. 863 patients (41.1%) were operated on through awake surgery and intraoperative mapping, while 1235 patients (58.8%) received asleep surgery and intraoperative electrophysiological monitoring or mapping. There was great heterogeneity between centers with some totally AW oriented (up to 100%) and other almost totally ASL oriented (up to 92%) (31% SD). For awake surgery, 79.9% centers preferred an asleep-awake-asleep anesthesia protocol. Only 53.3% of the centers used ECoG or transcutaneous EEG. The incidence of intraoperative seizures varied significantly between centers, ranging from 2.5% to 54% (p < 0.001). It there appears to be a statistically significant link between the mastery of mapping technique and the risk of intraoperative seizures. Moreover, history of preoperative seizures can significantly increase the risk of intraoperative seizures (p < 0.001). Intraoperative seizures occurrence was similar in patients with or without perioperative drugs (12% vs. 12%, p = 0.2). This is the first European survey to assess intraoperative functional mapping and monitoring protocols and the management of peri- and intraoperative seizures. This data can help identify specific aspects that need to be investigated in prospective and controlled studies.
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