ReviewClinical medicine (London, England)2016
Restless legs syndrome.
Review in Clinical medicine (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Impairment of executive functions due to sleep alterations: An integrative review on the use of P300.Frontiers in neuroscience · 2022Pooled it
- The prevalence of Restless Legs Syndrome/Willis-ekbom disease (RLS/WED) in the third trimester of pregnancy: a systematic review.BMC neurology · 2020Pooled it
- Irritable bowel syndrome and restless legs syndrome: a narrative review of epidemiological and pathophysiological overlap.Annals of medicine and surgery (2012) · 2026Review
- Article
- Review
- Reported daytime sleepiness in relation to orthopnea, restless legs and nocturia in patients evaluated for suspected obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Article
- Association of Sleep Problems With Dialysis Shifts in Patients Undergoing Hemodialysis in Tbilisi, Georgia.Cureus · 2024Article
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Evaluation of the relationship between idiopathic restless legs syndrome and serum hepcidin levels.Brain and behavior · 2023Article
- Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?Brain and behavior · 2023Article
- Restless legs syndrome in DNAJC12 deficiency.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Five Things to Know About Restless Legs Syndrome in Patients on Dialysis.Canadian journal of kidney health and disease · 2023Article
- Article
- Microstructural changes of basal ganglia in migraine with restless legs syndrome: findings from a neuroimaging study.Sleep and biological rhythms · 2022Article
- [Identification of restless legs syndrome in polysomnography studies and its association with other variables].Revista de neurologia · 2022Article
- Association of HMOX-1 rs2071747 with sporadic Parkinson's disease in southern Han Chinese.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Sleep Quality: A Narrative Review on Nutrition, Stimulants, and Physical Activity as Important Factors.Nutrients · 2022Review
- The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is a common movement disorder characterised by an uncontrollable urge to move because of uncomfortable, sometimes painful sensations in the legs with a diurnal variation and a release with movement. The pathophysiology is only partially known and a genetic component together with dopaminergic and brain iron dysregulation plays an important role. Secondary causes for RLS need to be excluded. Treatment depends on the severity and frequency of RLS symptoms, comprises non-pharmacological (eg lifestyle changes) and pharmacological interventions (eg dopaminergic medication, alpha-2-delta calcium channel ligands, opioids) and relieves symptoms only. Augmentation is the main complication of long-term dopaminergic treatment of RLS. This article will provide a clinically useful overview of RLS with provision of diagnostic criteria, differential diagnoses, possible investigations and different treatment strategies with their associated complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.