Evidence map›Paper›PMID 27481363›Full record

ArticleEndocrine2017

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors.

Germano Gaudenzi, Manuela Albertelli, Alessandra Dicitore, Roberto Würth, Federico Gatto, Federica Barbieri, Franco Cotelli, Tullio Florio, Diego Ferone, Luca Persani and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Multifaceted modeling of small intestinal neuroendocrine tumors.Endocrine oncology (Bristol, England) · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Carcinoid Syndrome: Preclinical Models and Future Therapeutic Strategies.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. One Host-Multiple Applications: Zebrafish (International journal of molecular sciences · 2022
    Review
  19. Zebrafish Models of Paediatric Brain Tumours.International journal of molecular sciences · 2022
    Review
  20. Modeling Lung Carcinoids with Zebrafish Tumor Xenograft.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Germano GaudenziDepartment of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy.
Manuela AlbertelliDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Alessandra DicitoreLaboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Roberto WürthDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Federico GattoDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Federica BarbieriDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Franco CotelliDepartment of Biosciences, University of Milan, Milan, Italy.
Tullio FlorioDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Diego FeroneDepartment of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Luca PersaniDepartment of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy.
Giovanni VitaleDepartment of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-2478-683X
University of Genoa · ITUniversity of Milan · ITIRCCS Istituto Auxologico Italiano · ITOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical research on neuroendocrine tumors usually involves immortalized cell lines and few animal models. In the present study we described an in vivo model based on patient-derived xenografts of neuroendocrine tumor cells in zebrafish (Danio rerio) embryos, allowing a rapid analysis of the angiogenic and invasive potential. Patient-derived neuroendocrine tumor cells were transplanted in 48 hours post-fertilization Tg(fli1a:EGFP)

Indexed as

AdultAgedAnimalsDrug Evaluation, PreclinicalFemaleHeterograftsHumansMaleMiddle AgedNeoplasm TransplantationNeovascularization, PathologicNeuroendocrine TumorsPrimary Cell CultureTranslational Research, BiomedicalZebrafishAngiogenesisNeuroendocrine tumorsPatient-derived xenograftsZebrafish

Identifiers

PMID27481363
OpenAlexW2490812923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.